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Performing gastric bypass surgery on patients severely changes their gut hormone response to glucose. The plasma concentrations of Insulin and a number of associated incretin peptides are significantly raised shortly after ingestion of glucose. Typically the plasma concentrations of these peptides a...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD016690 | Pride
A proteomic and peptidomics analysis of serum from patients suffering from metabolic dysfunction-associated steatotic liver disease. Proteomics was performed initially on a set of patients with varying degrees of liver disease. Following close analysis of the results, a peptidomics based analysis wa...
ORGANISM(S): Homo sapiens (Human) 
2025-01-21 | PXD052061 | Pride
Cells labelled with the TPH1-venus fluorescent protein were sorted and collected for peptidomics analysis. Cells that were TPH1 negative were also collected and analysed.
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD062039 | Pride
To characterise the impact of metabolic disease on the peptidome of human and mouse pancreatic islets and the contribution of intra-islet glucagon-like peptide 1 (GLP-1) receptor signalling.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-08-24 | PXD026095 | Pride
Characterisation of the secretome of placental organoids using Liquid Chromatography and Mass Spectrometry by performing solid phase extraction of the supernatants, followed by tryptic digestion.
ORGANISM(S): Homo sapiens (Human) 
2018-11-29 | PXD009118 | Pride
The aim of the project is to generate a peptidomics map of gut hormone peptides along the gastrointestinal tract, starting with the stomach and including the duodenum, jejunum, ileum, ascending colon, sigmoid colon and rectum. The tissues would be collected after surgery and the peptide fraction ext...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD009788 | Pride
Mammalian cells were grown as multicellular aggregates (spheroids) in an effort to determine the signaling events required for two cellular transformations states; primary foreskin fibroblasts (HFF-2) and glioblastoma cancer (T98G) cells, to survive at room temperature under oxygen and nutrient-depr...
ORGANISM(S): Homo sapiens 
Mammalian cells were grown as multicellular aggregates (spheroids) in an effort to determine the signaling events required for two cellular transformations states; primary foreskin fibroblasts (HFF-2) and glioblastoma cancer (T98G) cells, to survive at room temperature under oxygen and nutrient-depr...
ORGANISM(S): Homo sapiens 
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