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ProteomicsL-Glyceraldehyde inhibits neuroblastoma cell 1 growth via a multi-modal mechanism on metabolism 2 and signaling
Glyceraldehyde (GA) is a 3-carbon monosaccharide that can be present in cells as a by-product of fructose metabolism. Bruno Mendel and Otto Warburg showed that the application of GA to cancer cells inhibits glycolysis and their growth. This phenomenon was extensively studied up until the 1970’s. How...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD048695 | Pride
Metabolism Neuroblastoma Cancer Redox Glycolysis 
UnknownThe SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0): an analysis of European S-ICD clinical practice and its evolution in paediatric patients.
Not available
S-EPMC12658323 | biostudies-literature
UnknownApplication of Novel Technologies in Cardiac Electrotherapy to Prevent Complications.
Not available
S-EPMC10178181 | biostudies-literature
ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
ProteomicsHEK293 Quality Control example dataset - contamination test
A simple HEK293 lysate, with two files containing a putative mycoplasma contamination, and two negative control samples, taken from Geiger etc al. (Mol Cell Proteomics. 2012 Mar;11(3):M111.014050. doi: 10.1074/mcp.M111.014050. Epub 2012 Jan 25.) [PXD002395].
ORGANISM(S): Homo sapiens (Human) 
2015-11-04 | PXD003134 | Pride
Mycoplasma Ptxqc Hek293 
ProteomicsHEK293 Quality Control example dataset
A simple HEK293 lysate, which can be used to benchmark the performance of both the LC system and the mass spectrometer. The four files uploaded here were aqcuired on different timepoints and show distinct LC column differences.
ORGANISM(S): Homo sapiens (Human) 
2015-11-02 | PXD003133 | Pride
Hek293 Ptxqc 
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP]
Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish i...
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33569 | biostudies-arrayexpress
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites
This SuperSeries is composed of the following subset Series: GSE33569: In vivo and transcriptome-wide identification of RNA-binding protein target sites [PAR-CLIP] GSE33573: In vivo and transcriptome-wide identification of RNA-binding protein target sites [RNA-Seq] Refer to individual Series
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33543 | biostudies-arrayexpress
ProteomicsProteomic analysis of successful and biologically compromised bone fracture healing
Bone fracture healing shows approximately 10-15% non-unions, although theoretically it has the potential of scarless regeneration. With regards to our aging society, a better understanding of the healing process is needed to allow for more sophisticated treatment options. Particular the early phase,...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD020085 | Pride
Lc-ms Bone Rattus norvegius 
TranscriptomicsIn vivo and transcriptome-wide identification of RNA-binding protein target sites [RNA-Seq]
Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive nucleosides to crosslink RBPs to target RNAs in cells prior to immunoprecipitation. Here, we establish i...
ORGANISM(S): Caenorhabditis elegans 
2011-12-09 | E-GEOD-33573 | biostudies-arrayexpress
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