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ProteomicsHEK293 Quality Control example dataset
A simple HEK293 lysate, which can be used to benchmark the performance of both the LC system and the mass spectrometer. The four files uploaded here were aqcuired on different timepoints and show distinct LC column differences.
ORGANISM(S): Homo sapiens (Human) 
2015-11-02 | PXD003133 | Pride
Hek293 Ptxqc 
ProteomicsHEK293 Quality Control example dataset - contamination test
A simple HEK293 lysate, with two files containing a putative mycoplasma contamination, and two negative control samples, taken from Geiger etc al. (Mol Cell Proteomics. 2012 Mar;11(3):M111.014050. doi: 10.1074/mcp.M111.014050. Epub 2012 Jan 25.) [PXD002395].
ORGANISM(S): Homo sapiens (Human) 
2015-11-04 | PXD003134 | Pride
Mycoplasma Ptxqc Hek293 
ProteomicsProteomic and phosphoproteomic profiling reveals ACSS2 facilitating metabolic support in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignancy of transformed hematopoietic progenitors, which is curable in only 25-50% of patients thus the risk of relapse remains the major challenge. Considerable efforts in improving outcome through the understanding of AML biology elucidate that AML is not autono...
ORGANISM(S): Homo sapiens (Human) 
2024-06-11 | PXD032051 | Pride
Aml Shotgun proteomics Phosphoproteomics 
ProteomicsSequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's disease and related neurodegenerative diseases. Lowering αSyn is being actively investigated as a therapeutic modality. Here we systematically map the regulatory network that controls endogenous αSyn using sequ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD048283 | Pride
Crispr Alpha-synuclein Natb inhibition Parkinson's disease Human neurons 
ProteomicsThe Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers
Ig diversification occurs in peripheral lymphoid organs after establishment of central tolerance during B cell development. In germinal centers (GCs), somatic hypermutation of Ig genes occurs in dark zones, followed by selection of mutated clones in light zones (LZs). This generates high-affinity Ig...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-12 | PXD040978 | Pride
B-cell Germinal center Autoimmunity Ubiquitin ligase 
ProteomicsComparative evaluation of different sample preparation workflows for reproducible, quantitative, and in-depth analysis of urine proteomics
The growing field of urinary proteomics has provided a promising opportunity to identify biomarkers useful for diagnosis and prognostication of a number of diseases. Urine is abundant and readily collected in a non-invasive manner which makes it eminently available for testing, however sample prepar...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD016273 | Pride
Reproducibility Urine proteomics Mass spectrometry Preomics ist Mstren Sample preparation Label-free S-trap 
ProteomicsCul4b promotes CD4 T cell expansion by aiding the repair of damaged DNA
The capacity for T cells to become activated and clonally expand during pathogen invasion is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling prepares cells for this rapid expansion remains limited. We have identified an E3 ubiquitin ligase, Cul4b, that regul...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD017699 | Pride
Dcaf1 Crl4 E3 ubiquitin ligase T cell receptor Apoptosis Smc1a Cul4b Cell cycle T cells Proliferation Adaptive immune response Dna damage response 
ProteomicsProteomic Screening Identifies Novel Biomarkers and Mechanisms of Synovial Joint Disease in a Canine Model of Mucopolysaccharidosis I
Mucopolysaccharidosis I is a lysosomal storage disorder characterized by deficient alpha-L-iduronidase activity, leading to abnormal accumulation of glycosaminoglycans in cells and tissues. Synovial joint disease is prevalent and significantly reduces patient quality of life. There is a critical nee...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-05-22 | PXD037130 | Pride
Canine model Mucopolysaccharidosis Synovial fluid Serum Synovial joint disease 
ProteomicsEffects of miRNA-30a 5p knock down in bone marrow CD71-positive erythroid precursor cells (imBMEP-A)
Ex vivo production of red blood cells (RBCs) represents a promising alternative for transfusion medicine. Several strategies were described to generate erythroid cell lines from different sources, including embryonic, induced pluripotent and hematopoietic stem cells. With imBMEP-A, we have previousl...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD071954 | Pride
Mirna-30a Erythropoesis Proteome 
ProteomicsHepatomasys
Metabolic alterations can serve as targets for diagnosis and therapy of cancer. Due to the highly complex regulation of cellular metabolism, definite identification of metabolic pathway alterations remains challenging and requires sophisticated experimentation. Here, we applied a comprehensive kinet...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD011162 | Pride
Shotgun proteomics Mass spectrometry Liver cancer Hepatocellular carcinoma 
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