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ProteomicsIn vivo proximity labeling identifies the interactome of the endoribonuclease Zucchini in Drosophila ovary.
PIWI-interacting RNAs (piRNAs) are small RNAs that play a conserved role in genome defense by silencing transposable elements. The piRNA processing pathway is dependent on the sequestration of RNA precursors and protein factors in specific subcellular compartments. Therefore, a highly resolved spati...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-08 | PXD036182 | Pride
Turboid Drosophila Proximity labeling Lc-ms/ms 
ProteomicsMechanisms of Chemotherapy Failure in Refractory/Relapsed Acute Myeloid Leukemia: The Role of Cytarabine Resistance and Mitochondrial Metabolism
Acute myeloid leukemia (AML) originates from malignant, immature myeloid progenitor cells that differentiate into dysfunctional myeloblasts. While cytarabine (Ara-C) and daunorubicin (DNR)-based chemotherapy regimens are the standard treatments, approximately 10-40% of AML patients under the age of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054797 | Pride
Mitochondrial metabolism Acute myeloid leukemia Cytrabine 
ProteomicsMaximally-multiplexed proteome quantification platform for isotopic metabolic and chemical labeling
Quantitative proteomic platforms based on precursor intensity in mass spectrometry (MS1-level) uniquely support in vivo metabolic labeling with superior quantification accuracy but suffers from limited multiplexity (≤3-plex) and frequent missing quantities. Herein, we present a maximally-multiplexed...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD009952 | Pride
Diethylation Heat shock Silac-6plex Protein quantification Hela cell Quantification Silac De-6plex Heat shock response 
ProteomicsEpigenetic resetting in the Parkinson's disease entail histone modification remodeling.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disrupted cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD067971 | Pride
Human Tmt Parkinson's Organoid Lc-ms/ms 
ProteomicsProtein-RNA interaction dynamics downstream of KRAS activation reveals key regulators of oncogenic KRAS driven cancers.
Oncogenic KRAS mutations rewires cellular signaling, leading to significant alterations in gene expression. RNA-binding proteins (RBPs) play a pivotal role in gene expression regulation by post-transcriptionally controlling various aspects of RNA metabolism. It becomes clear that interactions betw...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053310 | Pride
Human Lung Rbp 
ProteomicsRBS-ID: Comprehensive identification of RNA-binding sites at single amino acid-resolution
We developed RBS-ID, which greatly simplifies the RNA moiety by chemical cleavage, reducing the complexity of MS/MS search space to accurately identify and localize RBS in peptides. RBS-ID comprehensively and robustly identifies RNA-binding sites at both proteome and single protein level.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-06-02 | PXD016254 | Pride
Human Rbp. rbs Rna Lc-ms/ms 
ProteomicsSerpina1e mediates the exercise-induced enhancement of hippocampal memory
Although exercise improves cognition, the specific molecules responsible for these beneficial effects remain unclear. Here, we propose that the myokine Serpina1e acts as a molecular mediator for these effects. Using an in vivo myokine-labeling mouse model, we confirmed that the Serpina1 family of pr...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD055604 | Pride
Exercise Hippocampus Cognitive enhancement Serpina1e Skeletal muscle Memory Neurogenesis Bdnf Myokine 
ProteomicsSuper-resolution proximity labeling method with enhanced direct identification of biotinylation sites
Promiscuous labeling enzymes, such as APEX2 or TurboID, are commonly used in in situ biotinylation studies of subcellular proteomes or protein-protein interactions. Although the conventional approach of enriching biotinylated proteins is widely implemented, in-depth identification of specific biotin...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047979 | Pride
Biotinylation site Apex2 Turboid Lc-ms Membrane protein topology Bioid Proximity labeling 
ProteomicsMm_iPS_iTRAQ
Proteome dynamics of mouse embryonic fibroblast reprograming into iPS cells
ORGANISM(S): Mus Musculus 
2014-12-31 | PAe005212 | PeptideAtlas
TranscriptomicsThe fine-scale and complex architecture of human copy number variation
Despite considerable excitement over the potential functional significance of copy number variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of CNV regions in the human genome. In this study, we used a high-resolution array-based comparative genomic hybridi...
ORGANISM(S): Homo sapiens 
2008-01-23 | E-GEOD-9831 | biostudies-arrayexpress
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