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ProteomicsFatty acid transport protein 2 interacts with ceramide synthase 2 to regulate ceramide synthesis
Dihydroceramide is generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, namely sphinganine and fatty acyl CoAs. Sphinganine is generated via the sequential activity of two integral membrane proteins located in the endoplasmic reticulum. Less is known about the s...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031088 | Pride
Ceramide synthase Dihydroceramide Ceramide Fatty acid transport protein Sphingolipids 
ProteomicsA toolbox for systematic discovery of stable and transient protein interactors in baker’s yeast
Identification of both stable and transient interactions is essential for understanding protein function and regulation. While assessing stable interactions is more straightforward, capturing transient ones is challenging. In recent years, sophisticated tools have emerged to improve transient intera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-01 | PXD033348 | Pride
Substrate discovery Turboid Yeast libraries Interaction profiling 
ProteomicsIn search of Varroa chemosensory related proteins using transcriptomic and proteomic tools
The tight synchronization between the life cycle of the obligatory parasitic mite Varroa destructor (Varroa) and its host the honeybee, is mediated by honeybee chemical stimuli. These stimuli are mainly perceived by a pit organ located at the distal part of the mite’s foreleg. In the present study, ...
ORGANISM(S): Varroa destructor 
2018-11-21 | PXD010042 | Pride
Forelegs Odorant binding proteins Varroa mites Honeybee 
ProteomicsIdentification of new amniotic fluid prognostic biomarkers of congenital cytomegalovirus infection severity
Background: Congenital cytomegalovirus (cCMV) is a common intrauterine infection, leading to neurodevelopmental disabilities. Early prognostic assessment of the severity of cCMV has remained an ongoing challenge. We aimed to identify amniotic fluid biomarkers of the severity of cCMV-related fetal br...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2022-05-25 | PXD029105 | Pride
Cytomegalovirus  congenital cytomegalovirus infection  amniotic fluid biomarkers 
ProteomicsDYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
Effective protection from viral infections depends on the antibody-specific isotype. Here, we found that the protein kinase, DYRK1A, is essential for B cell-mediated protection from viral infection and vaccination through regulation of class switch recombination (CSR). Dyrk1a-deficient B cells were ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-16 | PXD034156 | Pride
Antibody Clonal selection B cell Class-switch recombination Humoral immunity 
ProteomicsDesigned high-redox potential laccases exhibit high functional diversity
White-rot fungi secrete an impressive repertoire of high-redox potential laccases (HRPLs) and peroxidases for efficient oxidation and utilization of lignin. Laccases are attractive enzymes for green-chemistry applications due to their broad substrate range and low environmental impact. Since express...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-16 | PXD034630 | Pride
Enzyme design Protein stability Heterologous expression Pross Enzyme promiscuity Funclib Lignin degradation Laccase 
ProteomicsLarge-scale proteomics analysis of five brain regions from Parkinson’s disease patients with a GBA1 mutation
Despite being the second most common neurodegenerative disorder, little is known about Parkinson’s disease (PD) pathogenesis. A number of genetic factors predispose towards PD, among them mutations in GBA1, which encodes the lysosomal enzyme acid-β-glucosidase. We now perform non-targeted, mass spec...
ORGANISM(S): Homo sapiens (Human) 
2024-02-19 | PXD047134 | Pride
Α-synuclein Lysosomal storage disorders Parkinson’s disease Gaucher disease Proteomics. 
ProteomicsTranscriptomic alterations induced by physiologically relevant level of mono(2-ethylhexyl) phthalate (MEHP) in oocytes and blastocysts
Mono(2-ethylhexyl) phthalate (MEHP), the main di(2-ethylhexyl) phthalate (DEHP) metabolite, is a known reproductive toxicant. Residual levels of 20 nM MEHP have been found in follicular fluid aspirated from IVF-treated women and DEHP-treated animals. It is not yet clear whether these residual MEHP l...
ORGANISM(S): Bos taurus (Bovine) 
2019-05-09 | PXD012092 | Pride
Mehp Gene expression Phthalate Oocyte developmental competence Transcriptome 
ProteomicsImperfect Redundancy in the Family of Thylakoid Lumen Deg Proteases in Arabidopsis Helps Identifying Their Potential Substrates
Deg proteases are involved in protein quality control and response to stress in prokaryotic organisms. Out of the 16 Deg-encoding genes of Arabidopsis, the products of three, Deg1, Deg5 and Deg8, are located in the thylakoid lumen. Deg1 forms homo-hexamers, degrading photosynthetic proteins, especia...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-01-17 | PXD008920 | Pride
Deg proteins Thylakoids Arabidopsis 
ProteomicsGenetic Control Over Biogenic Crystal Morphogenesis in Zebrafish
Organisms had to evolve mechanisms that regulate the properties of biogenic crystals to support a wide range of functions, from vision and camouflage to communication and thermal regulation. Yet, the mechanism underlying the formation of diverse intracellular crystals remains enigmatic. Here, we hav...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-07-31 | PXD052468 | Pride
Guanine Iridophore Substrate selectivity Controlled biosynthesis Paralogous enzymes Crystal morphogenesis 
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