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ProteomicsPharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Astrocytes contain the majority of the brain’s supply of glycogen which has been suggested to play an important role in neuronal synaptic plasticity. This may be mediated by release of glycogen-derived lactate or glutamine supporting neuronal metabolism or via induction of neuronal signaling pathway...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2021-08-13 | PXD027901 | Pride
Mouse astrocytes Amp-activated protein kinase Energy metabolism Adenylyl cyclase Phosphorylation 
TranscriptomicsA two-component regulatory system controls serpin expression in Bifidobacterium breve UCC2003.
This work reports on the identification and molecular characterization of a two-component regulatory system (2CRS), encoded by serRK, which is believed to control the expression of the ser2003 locus in Bifidobacterium breve UCC2003. The ser2003 locus consists of two genes, Bbr_1319 (sagA) and Bbr_13...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-08-28 | E-GEOD-37835 | biostudies-arrayexpress
ProteomicsEnrichment of Cysteine S-palmitoylated peptides using Sodium Deoxycholate Acid Precipitation - SDC-ACE
S-palmitoylation is a poorly understood post-translational modification that is gaining more attention as an essential regulator of cellular processes. The reversible nature of S-palmitoylation allows for fine-tuned control of cellular events and adaptation to stimuli. The enrichment of S-palmitoyla...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2026-02-16 | PXD054682 | Pride
Cysteine palmitoylation  mouse brain palmitoylome  dbdb mice  mouse tissue specific palmitoylation 
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
ProteomicsCharacterization of signaling pathways associated with pancreatic beta-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db miceCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
To characterize the signaling mechanisms underlying beta-cell dysfunction in db/db mice and their return to a more “normal” beta-cell phenotype, we applied a mass spectrometry-based quantitative phosphophoproteomics and sialiomics(sialylated N-linked glycopeptides) approach to normal and db/db beta-...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-19 | PXD017469 | Pride
Beta-cells Obesity Islets Diabetes 
UnknownIntegrative systematics and ecology of a new deep-sea family of tanaidacean crustaceans.
Not available
S-EPMC6904764 | biostudies-literature
ProteomicsModelling Synaptic Maturation from Growth Cone to Synapse in Human Organoids
Human neural organoids (NOs) provide a powerful platform for investigating synaptic development and dysfunction during early neurodevelopment. However, methodologies for isolating functional synaptic structures from these models remain limited. Here, we present a differential centrifugation protocol...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-25 | PXD072589 | Pride
Synapse Synaptosomes Guided dorsal forebrain organoid Stimulation Nerve terminals Dynamin. Subcellular enrichment Proteomics Neural organoid Brain organoid Gap43 Phosphorylation Air-liquid interface cerebral organoid Growth cone Differential centrifugation 
UnknownThe role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
Not available
S-EPMC2999953 | biostudies-literature
MetabolomicsBioinspired Rhamnolipid Protects Wheat Against Zymoseptoria tritici Through Mainly Direct Antifungal Activity and Without Major Impact on Leaf Physiology

Rhamnolipids (RLs), glycolipids biosynthesized by the Pseudomonas and Burkholderia genera, are known to display various activities against a wide range of pathogens. Most previous studies on RLs focused on their direct antimicrobial activity, while only a few reports described t...

2022-06-21 | MTBLS4542 | MetaboLights
ProteomicsCellular signaling underlying GSIS in pancreatic β-cells
In the present study, we investigated signaling pathways associated with GSIS in freshly isolated rat Islets of Langerhans. Specifically, our aim was to reveal which phosphosites and N-linked sialylated glycosylation sites that were reversible regulated upon brief glucose stimulation and link these ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-11-14 | PXD007689 | Pride
Beta-cells Lc-msms Gsis Rat Islets 
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