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Glycosylation of proteins is one of the most common post-translational modification (PTM) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also a consistent part of the human tear film proteome mainta...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-01-25 | PXD038280 | Pride
The fucose-binding Aleuria aurantia lectin (AAL) labels punctiform structures in proximity to the nuclei of Toxoplasma gondii tachyzoites. We have utilized AAL-lectin affinity purification in conjunction with LC MS/MS to identify a set of proteins modified with fucose on serines and threonines
ORGANISM(S): Toxoplasma gondii 
2016-10-11 | PXD004426 | Pride
Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic re...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002913 | Pride
O-GlcNAc is thought to regulate proteins in a mannaer analogous to other PTMs, modulating cellular functions including the cellular stress response. The aim of this study was to identify specific cellular networks and protein complexes that are differentially O-GlcNAcylated and/or expressed upon acu...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-29 | PXD000849 | Pride
The zoonotic liver fluke Fasciola hepatica is responsible for economic losses to the agriculture industry worldwide. Triclabendazole has been the drug of choice. However, anthelmintic resistance is becoming prevalent with cases of resistance detected globally. This emphasizes the need for alternativ...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2026-06-29 | PXD035194 | Pride
The aim of this experiment is to compare nucleases used in ribosome profiling using Drosophila melanogaster Kc167 cells and human U2OS osteosarcoma cells. Ribosome profiling was performed from nuclease digested samples using sucrose cushion centrifugation separated ribosomes.
ORGANISM(S): Homo sapiens 
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