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ProteomicsEMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress
To illustrate EMP1-interacting proteins, we performed co-immunoprecipitation (co-IP) followed by mass spectrometry using HSPCs (Lin-c-Kit+) to characterize protein interactomes of EMP1. Murine HSPCs (Lin-c-Kit+) were infected with retrovirus to force EMP1 overexpression (with HA tag). Then IgG or HA...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-13 | PXD055884 | Pride
Hspcs Emp1 
UnknownGenetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features.
Not available
S-EPMC8046547 | biostudies-literature
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [Mouse lung macrophages]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074740 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [iBDMDs]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074476 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsProteomic and phosphoproteomic profiling of Lin⁻c-Kit⁺ cells from normal C57BL/6J mice and GFP⁺Lin⁻c-Kit⁺ cells from MLL-AF9-driven AML mouse model
Proteomic and Phosphoproteomic profiling of Lin⁻c-Kit⁺ cells from normal C57BL/6J mice and GFP⁺Lin⁻c-Kit⁺ cells from MLL-AF9-driven AML mouse model
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD077604 | Pride
Phosphoproteomic Proteomic Aml 
ProteomicsCK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation
1. LSCs from MLL-AF9-driven DekTg-fl, Tie2-Cre AML mice were sorted, followed by further proteomic assay. 2. To illustrate DEK-interacting proteins, we performed anti-Flag co-immunoprecipitation (co-IP) followed by mass spectrometry using MLL-AF9-driven LSCs to characterize protein interactomes of D...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD068965 | Pride
Pbx3 Dek Leukemia stem cells 
UnknownWorse Sleep Quality Aggravates the Motor and Non-Motor Symptoms in Parkinson's Disease.
Not available
S-EPMC9226540 | biostudies-literature
ProteomicsMetabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
ORGANISM(S): Mus Musculus 
2024-09-12 | PXD055797 |
ProteomicsGenome-wide Transcriptome and Proteome Profiling Indicate an Active Role of Alternative Splicing During De-etiolation of Maize Seedlings
The dramatic switch from skotomorphogenic to photomorphogenic development is an excellent system to elucidate both light signal transduction pathways and rapid developmental response to environmental stimuli in plants. To decipher the effects of various wavelengths of light on de-etiolation, we illu...
ORGANISM(S): Zea Mays 
2019-07-14 | PXD014602 |
ProteomicsDisrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
2022-07-14 | PXD035365 |
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