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ProteomicsEMP1 preserves hematopoietic stem cell potential under homeostasis and radiation-induced injury by alleviating ER stress
To illustrate EMP1-interacting proteins, we performed co-immunoprecipitation (co-IP) followed by mass spectrometry using HSPCs (Lin-c-Kit+) to characterize protein interactomes of EMP1. Murine HSPCs (Lin-c-Kit+) were infected with retrovirus to force EMP1 overexpression (with HA tag). Then IgG or HA...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-13 | PXD055884 | Pride
Hspcs Emp1 
UnknownGenetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features.
Not available
S-EPMC8046547 | biostudies-literature
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [Mouse lung macrophages]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074740 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [iBDMDs]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074476 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsProteomic and phosphoproteomic profiling of Lin⁻c-Kit⁺ cells from normal C57BL/6J mice and GFP⁺Lin⁻c-Kit⁺ cells from MLL-AF9-driven AML mouse model
Proteomic and Phosphoproteomic profiling of Lin⁻c-Kit⁺ cells from normal C57BL/6J mice and GFP⁺Lin⁻c-Kit⁺ cells from MLL-AF9-driven AML mouse model
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD077604 | Pride
Phosphoproteomic Proteomic Aml 
ProteomicsCK2-mediated DEK Phosphorylation Drives PBX3 Overexpression: A Core Event in Hematopoietic Stem Cell-to-Leukemia Stem Cell Transformation
1. LSCs from MLL-AF9-driven DekTg-fl, Tie2-Cre AML mice were sorted, followed by further proteomic assay. 2. To illustrate DEK-interacting proteins, we performed anti-Flag co-immunoprecipitation (co-IP) followed by mass spectrometry using MLL-AF9-driven LSCs to characterize protein interactomes of D...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD068965 | Pride
Pbx3 Dek Leukemia stem cells 
UnknownWorse Sleep Quality Aggravates the Motor and Non-Motor Symptoms in Parkinson's Disease.
Not available
S-EPMC9226540 | biostudies-literature
ProteomicsMetabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
ORGANISM(S): Mus Musculus 
2024-09-12 | PXD055797 |
ProteomicsDisrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
2022-07-14 | PXD035365 |
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