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TranscriptomicsExpression data from mouse embryonic stem cells and ES cell-derived definitive endoderm and early hepatic cells
Foxa2 is required for endoderm differentiation into the hepatic lineage. The mechanism of activation for Foxa2 during this developmental process has not been elucidated yet. We established an in vitro system to guide ES cells differentiating into definitive endoderm (DE) cells and the following DE c...
ORGANISM(S): Mus musculus 
2012-08-02 | E-GEOD-39854 | biostudies-arrayexpress
TranscriptomicsDNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements and chimaeric transcripts in mouse ES cells
DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) play important roles in silencing of genes and retroelements. However, a comprehensive comparison of genes and repetitive elements repressed by these pathways has not been reported. Here we show that in mouse embryonic stem cells (mESC...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29413 | biostudies-arrayexpress
ProteomicsBruton’s Tyrosine Kinase Degradation as a Therapeutic Strategy for Cancer
The covalent Bruton’s Tyrosine Kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it also has off-target effects and multiple mechanisms of resistance, including the C481S mutation. We hypothesized that small molecule-induced BTK degradation might ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-25 | PXD010568 | Pride
Imids Protac Crl4 Btk Ubiquitin Cullin 
GenomicsWhole Genome Association Study of Bipolar Disorder

The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease.

Dataset versioning

  • Version 1: European-American (EA) ancestr...
phs000017.v3.p1 | EGA
ProteomicsDegraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors
Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple host factors to remo...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD063557 | Pride
Degrader Dengue Capsin Virus Crbn Chemical biology Protac Ubiquitin 
ProteomicsDevelopment and Characterization of a Wee1 Kinase Degrader
The G1/S cell-cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells particularly reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Inhibiting regulators of the G2/M checkpoint can therefore drive cancer cells into premature mitosis, ultimately causing cel...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015513 | Pride
Cancer Wee1 Crl4 Crbn Protac Ubiquitin 
ProteomicsA Chemproteomics Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Heterobifunctional molecule that recruits E3 ubiquitin ligases, such as cereblon, for targeted protein degradation is an emerging pharmacological strategy. A major unanswered question is how generally applicable this strategy is to all protein targets. In this study, we designed a multi-kinase degra...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD007851 | Pride
Kinase 
ProteomicsA Chemproteomics Approach to Query the Degradable Kinome Using a Multi-kinase Degrader, part 2
Heterobifunctional molecule that recruits E3 ubiquitin ligases, such as cereblon, for targeted protein degradation is an emerging pharmacological strategy. A major unanswered question is how generally applicable this strategy is to all protein targets. In this study, we designed a multi-kinase degra...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD007861 | Pride
Kinase Ligand Protac 
TranscriptomicsTranscription profiling of human embryonic stem (ES) cells. Undifferentiated cells of different passage numbers (p19 and p128) were vs cells differentiated in hanging drops for 5 days (d5 embryoid bodies) or expanded on gelatin coated dishes for a further 9 days (d14 embryoid bodies)
Undifferentiated cells of different passage numbers (p19 and p128) were compared to cells differentiated in hanging drops for 5 days (d5 embryoid bodies) or expanded on gelatin coated dishes for a further 9 days (d14 embryoid bodies).
ORGANISM(S): Homo sapiens 
2005-08-31 | E-MEXP-303 | biostudies-arrayexpress
ProteomicsExploring targeted degradation strategy for oncogenic KRASG12C
KRAS is the most frequently mutated oncogene found in pancreatic, colorectal, and lung cancers. Although it has been challenging to identify targeted therapies for cancers harboring KRAS mutations, one particular form of mutant KRAS, namely KRASG12C, can be targeted by small molecule inhibitors that...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD014549 | Pride
Cancer protac Crl4 Crbn Kras Oncogene Ubiquitin 
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