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ProteomicsReduced mGluR5 activity modulates mitochondrial function in the synapse
The metabotropic glutamate receptor 5 (mGluR5) is a G-protein coupled receptor with an important role in synaptic function at multiple levels. In physiological conditions, mGluR5 is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an ackno...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-27 | PXD023809 | Pride
Mitochondria Dia Swath Brain Metabotropic glutamate receptor 5 Synapse Mass spectrometry Mice Mglur5 Ctep 
ProteomicsComparative analyses of data independent acquisition mass spectrometric approaches: DIA, WiSIM-DIA and directDIA
With a multitude of DIA approaches developed recently, many of their features are not yet well explored. In this study we make use of a biologically relevant sample, the synaptosome, as a model to compare the spectral libraries generated by (1) DDA solely on Orbitrap (OT), (2) Orbitrap for MS1 scan...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-20 | PXD006934 | Pride
Wisim-dia Lc-ms/ms Dia Wisim Dda Directdia 
ProteomicsComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynam...
ORGANISM(S): marmosets Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-22 | PXD009251 | Pride
Synapse Species Proteomics Rat Marmoset Human Synaptosome Mouse Swath 
ProteomicsThe effects of Sindbis viral vectors on neuronal function
Viral vectors are attractive tools to express genes in neurons. Transduction of neurons with a recombinant, replication-deficient Sindbis viral vector is a method of choice for studying the effects of short-term protein overexpression on neuronal function. However, to which extent Sindbis by itself ...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-26 | PXD013634 | Pride
Triple tof Proteomics Hippocampus Mouse Sindbis virus 
ProteomicsDynamics of the mouse brain cortical synaptic proteome during postnatal brain development
Development of the brain involves the formation and maturation of numerous synapses. This process requires prominent changes of the synaptic proteome and potentially involves thousands of different proteins at every synapse. To date the proteome analysis of synapse development has been studied spars...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004129 | Pride
Mouse Development Postnatal Cortex 
ProteomicsCasein kinase 1δ induces the formation of GVB-positive neurons that are resilient to tau-induced impairment of protein synthesis
The progressive intraneuronal accumulation of protein aggregates is central in the pathogenesis of several neurodegenerative diseases. Therefore, molecular pathways that mediate neuronal resilience to tau pathology present interesting targets for therapeutic intervention. To this end we investigated...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-09 | PXD061887 | Pride
Resilience Granulovacuolar degeneration bodies (gvbs) Tau Ck1δ 
ProteomicsGlycine receptor complex analysis using immunoprecipitation-blue native gel electrophoresis-mass spectrometry
The pentameric glycine receptor (GlyR), comprising the α1 and β subunits, is a major inhibitory ionotropic receptor in brainstem and spinal cord. GlyRs interact with gephyrin (GPHN), a scaffold protein that anchors the GlyR in the plasma membrane and enables it to form clusters in glycinergic postsy...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD017151 | Pride
Blue native gel electrophoresis Proteomics Protein complex Glycine receptor Iqsec3 
ProteomicsCorrelation profiling of synaptic sub-fraction proteomes of the mouse brain hippocampus, cortex and cerebellum
Synaptic transmission forms the main mode of signaling and information integration in the nervous system. Here, we identified and quantified proteins from three brain regions and five biochemical synapse sub-fractions. We identified around 4500 proteins in total, of which about 2000 proteins each we...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-25 | PXD005634 | Pride
Post synaptic density Synapse Proteomics Correlation profiling 
ProteomicsInteractomes of GluA1 and GluA3 subunit containing AMPARs reveal distinct protein composition
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. The most abundant AMPAR subtypes in the hippocampus are GluA1/2 and GluA2/3 heterotetramers. Each subtype contributes differentially to mechanisms of synaptic plasticity, which may be in pa...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD031603 | Pride
Proteomics Prrt1 Glua1/2 Tarp- γ8 Subcomplexes Ampar Glua2/3 Ms-dap 
ProteomicsAge-dependent hippocampal proteomics in the APP/PS1 Alzheimer mouse model: a comparative analysis with classical SWATH/DIA and directDIA approaches
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the human population, for which there is currently no cure. The cause of AD is unknown, however, the toxic effects of amyloid-β (Aβ) are believed to play a role in its onset. To investigate this, we examined changes in global ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-24 | PXD025777 | Pride
Proteomics Alzheimer Microglia App/ps1 mouse model Directdia Ms-dap 
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