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ProteomicsUBIQUITIN LIGASE STUB1 DESTABILIZES IFNγ-RECEPTOR COMPLEX TO SUPPRESS TUMOR IFNγ SIGNALING
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about 36 regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell sur...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD030580 | Pride
Immune checkpoint blockade Ubiquitination Ifnγ Stub1 Melanoma 
ProteomicsRNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8+ T cell antitumor activity. Although innate NK cells are triggered by loss of MHC class I, their response is often inadequate. To increase tumor susceptibility to both innate and adaptive...
ORGANISM(S): Homo sapiens (Human) 
2022-05-30 | PXD029489 | Pride
Rnf31 Tnf Ap 
ProteomicsTMED10 INHIBITION SUPPRESSES CELL-SURFACE PD-1 EXPRESSION AND REVERSES T CELL DYSFUNCTION
PD-1 immune checkpoint blockade (ICB) is revolutionizing cancer therapy, but little is known about the mechanisms governing its expression. In a whole-genome, dual-marker FACS-based CRISPR/Cas9 screen in primary murine CD8 T cells, we found that inactivation of the EMP24/GP25L/p24 protein family, mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD026984 | Pride
Pd-1 Lc-ms T-cell dysfunction Melanoma Tmed10 
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