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MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
ProteomicsHuman liver homogenate, liver microsomes, low-speed centrifugation pellet and hepatocytes LC-MS/MS from 15 matched donors
LC-MS/MS-based label-free proteomics of human liver homogenate, human liver microsomes, and human hepatocytes from 15 matched donors used to compare and understand differences in two major in vitro systems used for drug metabolism studies
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD014131 | Pride
Human Low-speed centrifugation pellet Hepatocytes Liver Liver microsomes Lc-ms/ms 
ProteomicsProteomic Analysis of Rat Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000720 | Pride
2d-lc-msms Tripletof Rat liver microsomes Proteinpilot 
ProteomicsProteomic Analysis of Human Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Homo sapiens (Human) 
2015-03-26 | PXD000721 | Pride
2d-lc-msms Tripletof Proteinpilot Human liver microsomes 
ProteomicsProteomic Analysis of Mouse Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Mus musculus (Mouse) 
2015-03-26 | PXD000731 | Pride
Mouse liver microsomes 2d-lc-msms Tripletof Proteinpilot 
Proteomicsmouse liver microsomes phosphorylation with LC-MS/MS
The microsomes are re-formed vesicle-like artifacts, not ordinarily present in living cells, from pieces of the endoplasmic reticulum (ER), plasma membrane, mitochondria, and Golgi apparatus of broken eukaryotic cells. Typically, microsomes are separated by differential centrifuged from homogenized ...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD003043 | Pride
Tio2 Phosphorylation Mouse liver microsome Lc-ms/ms 
Proteomicsmouse liver microsomes phosphorylation
The microsomes are re-formed vesicle-like artifacts, not ordinarily present in living cells, from pieces of the endoplasmic reticulum (ER), plasma membrane, mitochondria, and Golgi apparatus of broken eukaryotic cells. Typically, microsomes are separated by differential centrifuged from homogenized ...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-24 | PXD002221 | Pride
Mouse Phosphorylation Microsome Liver 
ProteomicsRat Liver Microsomes by 2D-LC-MS/MS
Rat liver microsomes were analysed using offline strong cation exchange fractionation followed by reverse-phase chromatography coupled to quadrupole-time-of-flight high-resolution mass spectrometry using trypsin and pepsin parallel digestions. MS/MS files were searched against the UniProt protein da...
ORGANISM(S): Rattus norvegicus (Rat) 
2013-02-19 | PXD000128 | Pride
Rat Strong cation exchange Microsomes Pepsin Liver Trypsin Qqtof 
ProteomicsSulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metaboing Enzymes as a Response to Redox Alteration
The lumen of the endoplasmic reticulum (ER) provides an oxidizing environment to aid in the formation of disulfide bonds, which is tightly regulated by both antioxidant proteins and small molecules. On the cytoplasmic side of the ER, cytochrome P450 (P450) proteins have been identified as a superfam...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-29 | PXD007913 | Pride
Human Dimedone Mouse Sulfenic acid Redox proteomics 
ProteomicsFunctional proteomics of membrane lipid domains after Brij 98 solubilization of uninduced and phenobarbital-induced rat liver microsomes: Defining the membrane localization of the P450 enzyme system
In this study, we use Brij 98 to determine the lipid domain distribution of the ER proteome in rat liver microsomes with emphasis on that of the P450 enzyme system. Because of the profound effects of phenobarbital treatment on protein expression and lipid biosynthesis, we will examine the liver ER p...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD022460 | Pride
Tmt discovery based proteomics P450s Liver microsomes 
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