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ProteomicsS-Sulfenylation regulates non-enzymatic oxidative protein folding
The post-translational modification S-Sulfenylation functions as a key sensor of oxidative stress yet the dynamics of sulfenic acids in proteins is largely elusive due to it's fleeting nature. LC-MS/MS analysis has detected the evolution of this modification in oxidative and reducing states.
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD004514 | Pride
Lc-ms/ms Post-translational modifications Human titin 
ProteomicsTailoring protein nanomechanics with chemical reactivity
The nanomechanical properties of elastomeric proteins determine the elasticity of a variety of tissues where modifications present at the covalent disulfide bonds can enhance protein stiffness. We propose an alternative chemical route to promote non-enzymatic oxidative protein folding via disulfide ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005981 | Pride
Lc-ms/ms Cysteine modifications 
ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
ProteomicsSox9 accelerates vascular ageing by regulating extracellular matrix composition and stiffness
Vascular calcification and increased extracellular matrix (ECM) stiffness are hallmarks of vascular ageing. Sox9 (SRY-Box Transcription Factor 9) is a master regulator of chondrogenesis, also expressed in the vasculature, that has been implicated in vascular smooth muscle cell (VSMC) osteo-chondroge...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD046001 | Pride
Vascular smooth muscle cells Sox9 Extracellular matrix Senescence 
ProteomicsMX2 Viral Substrate Breadth and Inhibitory Activity Are Regulated by Protein Phosphorylation
Productive infection by human immunodeficiency virus type-1 (HIV-1) requires the import of viral replication complexes into the nuclei of infected cells. Myxovirus resistance 2 (MX2/MxB) blocks this step, halting nuclear accumulation of viral DNA and virus replication. Here, we identify positions in...
ORGANISM(S): Homo sapiens (Human) 
2022-07-21 | PXD035305 | Pride
Innate immunity Mx2 Protein phosphorylation Infection Retroviruses 
ProteomicsProperties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes
The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. This study investigates the role of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056614 | Pride
Tau  alzheimer’s disease  astrocyte 
ProteomicsHuman glioblastoma derived cell line (U251) LC-MS
This study investigated the molecular mechanisms of specific medium chain fatty acids in a cellular model of cancer. These fatty acids are provided in the medium chain triglyceride (MCT) ketogenic diet, that is a widely used treatment for patients with drug resistant epilepsy, where the diet is comm...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD068251 | Pride
Glioblastoma Decanoic acid Gbm Mechanistic study Fatty acid metabolism Medium chain triglycerides (mct) Cancer 
ProteomicsVenom composition does not vary greatly between different nematocyst types isolated from the primary tentacles of Olindias sambaquiensis (Cnidaria: Hydrozoa)
A quantitative proteomic study to determine the variety and relative abundance of toxins present in two nematocyst types isolated from primary tentacles of adult medusa stage Olidias sambaquiensis. Quantitative proteomics was performed with Tandem Mass Tags (TMT) to compare similarities and also dif...
ORGANISM(S): Olindias sambaquiensis 
2019-08-26 | PXD012887 | Pride
Nematocyst Tmt quantitation Venom Cnidaria Lc-ms/ms 
ProteomicsCoordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention
The N371 site on PKCe was mutated to TAG in an expression plasmid. This was co-transfected in a 1:1 ratio with a plasmid that encodes both an aaRS optimised to recognise AbK, and the tRNAPyl which recognises the UAG codon.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025959 | Pride
14-3-3 pkce Mass spectrometry Phosphorylation 
ProteomicsCampylobacter gene regulation in C. jejuni
The pathogenic bacterium Campylobacter jejuni is the leading cause of bacterial foodborne gastroenteritis worldwide yet it does not grow in the aerobic environment. The paralogues RrpA and RrpB which are members of MarR family of DNA binding proteins have been shown to be important for the survival ...
ORGANISM(S): Campylobacter jejuni 
2021-11-03 | PXD028910 | Pride
Redox cycling Rrpa Rrpb 
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