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ProteomicsDeep Protein Arginine Asymmetric Di-Methylation Profiling of Breast Cancer Patient-derived Xenografts
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a prevalent posttranslational modification that regulates diverse cellular processes. Aberrant expression of type I PRMTs that catalyze asymmetric arginine demethylation (ADMA) is often found in cancer; however, little ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038203 | Pride
Breast cancer Pdx Adma Lc-ms/ms 
ProteomicsIsobaric labeling strategy utilizing 4-plex N, N-dimethyl leucine (DiLeu) tags reveals proteomic changes induced by chemotherapy-related neurotoxicity in cerebrospinal fluid of children
Using mass spectrometry for protein identification and quantification in cerebrospinal fluid (CSF) is at the forefront of research efforts to explore the pathophysiology biomarkers for the early diagnosis and prognosis of neurologic disorders. Here we implemented 4-plex N, N-dimethyl leucine (DiLeu)...
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD017415 | Pride
Leukemia Isobaric labeling Csf proteomics 
MetabolomicsGut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans

The gut microbiota is increasingly recognized for playing a critical role in human health and disease, especially in conferring resistance to both virulent pathogens such as Salmonella, which infects 1.2 million people in the United States every year [1], and opportunistic pathogens like Candida,...

2019-09-20 | MTBLS753 | MetaboLights
ProteomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Global proteome comparison between breast cancer MCF7 parental cell and PKM2 KO cell
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD007671 | Pride
Lc-ms Breast cancer 
ProteomicsUrinary Metabolomic and Proteomic Analyses of a Prostatic Inflammation Mouse Model
Lower urinary tract symptoms (LUTS) relate to storage and/or voiding disturbances which are common among aging men. Disease etiology is largely unknown, and diagnosis is currently based on subjective symptom scores. While mainstay treatments can be ineffective and bothersome, biomarker discovery eff...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-03 | PXD018023 | Pride
Proteomics Prostatic inflammation Isobaric labeling Metabolomics Urine Mass spectrometry Metandem Label free. Lower urinary tract symptoms 
ProteomicsIn depth quantification of extracellular matrix proteins from human pancreas
Extracellular matrix (ECM) is an important component of the pancreatic microenvironment which regulates β cell proliferation, differentiation and insulin secretion. Protocols have recently been developed for the decellularization of the human pancreas to generate functional scaffolds and hydrogels. ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD012460 | Pride
Tissue engineering Sample preparation Quantitative proteomics Ecm 
ProteomicsSurfactant and chaotropic agent assisted sequential extraction/on pellet digestion (SCAD) for enhanced proteomics
As a popular sample preparation approach, Filter-aided sample preparation (FASP) has been widely used in proteomic analysis. However, several limitations have been noted, including sample loss during filtration, repetitive centrifugation steps, and the possibility of breakage of filtration membrane....
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008967 | Pride
Urea Protein digestion Protein detection Protein extraction Peptide sequencing Lfq Scad Ibaq Fasp 
ProteomicsIncreased expression of SLC25A1/CIC in the mouse results in an autistic-like phenotype with altered white matter microstructure and neuron morphology
Ne-lysine acetylation within the lumen of the endoplasmic reticulum (ER) is a recently characterized protein quality control system that positively selects properly folded glycoproteins in the early secretory pathway. Overexpression of the ER acetyl-CoA transporter AT-1 in mouse forebrain neurons re...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-26 | PXD025415 | Pride
Dileu labeing Acetyl-coa Autism spectrum disorder Lc-ms/ms 
ProteomicsHigh-throughput Quantitative Glycomics Enabled by 12-plex Isobaric Multiplex Labeling Reagents for Carbonyl-Containing Compound (SUGAR) Tags
Glycans, which are widely distributed on most proteins and cell surfaces, are a class of important biomolecules playing important roles in various biological processes such as immune response and cellular communication. Modern mass spectrometry (MS) and novel chemical probes together greatly facilit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD038501 | Pride
N-glycan Lc-ms/ms Isobaric labeling 
ProteomicsGlobal Neuropeptidome Profiling in Response to Post-traumatic Stress Disorder in Rat
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that affects the health of a wide range of the population. However, its underlying neurophysiological mechanisms remain unclear due to the limited understanding of neuronal signaling molecules such as neuropeptides. Here, we developed m...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD038470 | Pride
Lc-ms/ms Neuropeptide Ptsd 
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