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ProteomicsLaser microdissection and mass spectrometry shows loss of podocyte proteins in minimal change disease and focal segmental glomerulosclerosis.
Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) are common causes of nephrotic syndrome. Both diseases present with massive proteinuria and widespread foot process effacement on electron microscopy examination. On the other hand, secondary FSGS can also present with sign...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD057165 | Pride
Laser microdissection Focal segmental glomerulosclerosis Mass spectrometry Minimal change disease 
ProteomicsFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We h...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD055559 | Pride
Kidney transplant. Fat1 De novo membranous nephropathy 
ProteomicsApolipoprotein E is associated with dense deposits in dense deposit disease
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway (AP) of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both C3GN and DDD are characterized by bright glomerular C3 staining on immunofluorescence studies. However...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD045319 | Pride
Human Tandem mass spectrometry Kidney Lcm Glomeruli 
ProteomicsProteomic and Phosphoproteomic Signatures of Disease Progression in Unmutated IGHV Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) patients with an unmutated (UM) immunoglobulin heavy chain variable region gene (IGHV) typically have poorer prognosis and require earlier treatment compared to those with mutated IGHV. Nevertheless, disease progression among UM-CLL patients is heterogeneous, with ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072006 | Pride
Phosphoproteomics Chronic lymphocytic leukemia Disease progression Unmutated ighv Proteomics 
ProteomicsLoss of ERG in human lung endothelial cells leads to release of pro-inflammatory and pro-fibrotic factors.
: Although vascular dysfunction is a hallmark of chronic aging-associated diseases, including idiopathic pulmonary fibrosis, the role of the pulmonary vasculature to lung repair versus lung fibrosis is not fully understood. We identified the endothelial transcription factor ETS-related gene (ERG) as...
ORGANISM(S): Homo sapiens (Human) 
2022-06-24 | PXD033847 | Pride
Lung Vasculature Erg Fibrosis 
ProteomicsHuman melanoma-derived extracellular vesicles reprogram dendritic cells potentially enabling lymph node metastases
Evolution of melanoma from a primary tumor to widespread metastasis is crucially dependent on lymphatic spread. The mechanisms regulating the initial step in metastatic dissemination via regional lymph nodes remain largely unknown. We have previously described a dysfunctional immune profile that pre...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005539 | Pride
Metastasis4 Dendritic cells2 Lymphatics3 Extracellular vesicles1 Tumor immunology5 
ProteomicsPhlpp1 alters the murine chondrocyte phospho-proteome during endochondral bone formation
Appendicular skeletal growth and bone mass acquisition are controlled by a variety of growth factors, hormones, and mechanical forces in a dynamic process called endochondral ossification. In long bones, chondrocytes in the growth plate proliferate and undergo hypertrophy to drive bone lengthening a...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-22 | PXD055563 | Pride
Endochondral ossification Proteomics Multi-omics Phospho-proteomics Transcriptomics Phlpp2 
ProteomicsThe Ratio of Immunogenicity: A Novel Metric to Rank the Relative Strength of an Individual Antigen’s Capacity to Stimulate an Antigen-Specific IgG Response.
Across the fields of immunology and medicine, the ability to identify and develop therapeutic strategies against primary (i.e. inciting) and secondary (i.e. perpetuating) antigenic proteins has potential to transform basic science and clinical practice. Despite significant in silico and in vitro adv...
ORGANISM(S): Bos taurus (Bovine) 
2026-05-25 | PXD058178 | Pride
Lc-msms Antigen detection Immune response Bovine pericardium 
ProteomicsThe Ratio of Immunogenicity: A Novel Metric to Rank the Relative Strength of an Individual Antigen’s Capacity to Stimulate an Antigen-Specific IgG Response.
Across the fields of immunology and medicine, the ability to identify and develop therapeutic strategies against primary (i.e. inciting) and secondary (i.e. perpetuating) antigenic proteins has potential to transform basic science and clinical practice. Despite significant in silico and in vitro adv...
ORGANISM(S): Bos taurus (Bovine) 
2026-05-25 | PXD058106 | Pride
Lc-msms Antigen detection Immune response Bovine pericardium 
ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
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