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To understand how GIPC3 exerts its effects on cuticular plate dimensions, we examined the GIPC3 protein-interaction network in hair cells. We immunoaffinity purified GIPC3 from crosslinked chicken inner ear extracts that were enriched for stereocilia, but still contain large amounts of hair-cell cyt...
ORGANISM(S): Gallus gallus (Chicken) 
2023-05-09 | PXD038234 | Pride
Respiratory Syncytial Virus (RSV) causes severe inflammation and airway pathology in children and the elderly by infecting the epithelial cells of the upper and lower respiratory tract. RSV replication is sensed by intracellular pattern recognition receptors upstream of the IRF and NF-$\upkappa$B tr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD023983 | Pride
Bromodomain-containing Protein 4 (BRD4) is a transcriptional regulator associated with cancer biology, inflammation, and fibrosis. In airway viral infection, non-toxic BRD4-specific inhibitors (BRD4i) block the release of pro- inflammatory cytokines and prevent downstream remodeling. Although the ch...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD039212 | Pride
In photosynthesis, light is absorbed by the thylakoid embedded light harvesting pigment protein complexes (LHCs) that surround the photosynthetic reaction centers, photosystem II (PSII) and photosystem I (PSI). The distribution of light energy between the photosystems is balanced through state trans...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-07-03 | PXD007630 | Pride
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