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ProteomicsProteomic Atlas of the Human Brain in Alzheimer’s Disease
Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small var...
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD010603 | Pride
Brain Alzheimer's Human Neurodegeneration 
ProteomicsProteomic Atlas of the Human Brain in Alzheimer’s Disease
Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small var...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD012131 | Pride
Brain Alzheimer's Human Neurodegeneration 
ProteomicsProteomic and Metabolomic Profiling of Acute and Chronic Stress Events Associated with Military Exercises
By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance and fatigue. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an ef...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD026680 | Pride
Human saliva stress 
MetabolomicsProteomic and metabolomic profiling of acute and chronic stress events associated with military exercises.
By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an effort to facil...
2023-12-05 | MTBLS5463 | MetaboLights
ProteomicsExtracellular matrix proteolysis maintains synaptic plasticity during brain development
Synapses are highly dynamic during early brain development, enabling the rapid adaptations that occur as neural circuits remodel in response to experience. The extracellular matrix (ECM) has been proposed as a critical regulator of synaptic plasticity in the brain. However, the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD060477 | Pride
Synaptic plasticity Synapse Extracellular matrix Brain development 
ProteomicsLysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction
The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abnormalities and mitochondrial dysfunction. Lysosomes are poised at the convergence point between thes...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD044942 | Pride
Lgals3bp Apms Mass spectrometry Apoe 4 Alzheimer’s disease Lysosomes 
ProteomicsGlobal discovery of synapse proteins using multi-omic synaptic signatures
Bottom-up proteomics analysis of whole cell lysate and synaptosomes extracted from wild type and Cul3-haploinsufficient mouse cortex
ORGANISM(S): Mus musculus (Mouse) 
2026-03-09 | PXD041108 | Pride
Synaptosome Lc-msms 
ProteomicsProteomic Atlas of the Human Brain in Alzheimer’s Disease
Here we provide a proteomic resource comprising nine functionally distinct sections from three individuals clinically diagnosed with Alzheimer's disease, across a spectrum of disease progression. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small var...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088398 | MassIVE
ProteomicsMerlin S13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features
Meningiomas are the most common primary intracranial tumors and are associated with inactivation of the tumor suppressor NF2/Merlin, but one-third of meningiomas retain Merlin expression and typically have favorable clinical outcomes. Biochemical mechanisms underlying Merlin-intact meningioma growth...
ORGANISM(S): Homo sapiens (Human) 
2024-07-04 | PXD053578 | Pride
Wnt signaling Proximity labeling Meningioma Mri Phosphoproteomics 
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