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ProteomicsRenal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione
Renal oncocytomas are rare benign tumors of the kidney and are characterized by a deficient complex I (CI) enzyme activity of the oxidative phosphorylation (OXPHOS) system caused by mitochondrial DNA (mtDNA) mutations. Yet, little is known about the underlying molecular mechanisms and alterations of...
ORGANISM(S): Homo sapiens (Human) 
2017-11-21 | PXD007633 | Pride
Renal oncocytoma - complex i deficiency - glutathione metabolism - mtdna mutation 
ProteomicsMutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer
Complex I (CI) is the first enzyme of the mitochondrial respiratory chain and couples the electron transfer with proton pumping. Mutations in genes encoding CI subunits can frequently cause inborn metabolic errors. We applied proteome and metabolome profiling of patient-derived cells harboring patho...
ORGANISM(S): Homo sapiens (Human) 
2019-10-16 | PXD009743 | Pride
Proteome profiling Ndufs1 Metabolome profiling Mt-nd5 Mitochondrial complex i 
ProteomicsIdentification of universally applicable and species-specific marker peptides for Bacillus anthracis
Anthrax is a zoonotic infection caused by the bacterium Bacillus anthracis (BA), a gram-positive, aerobic, spore-forming bacterium that can be misused as a biowarfare agent. The major patho-genicity factors of BA are encoded by genes located on two extrachromosomal plasmids, which are often targeted...
ORGANISM(S): Bacillus anthracis Bacteria 
2023-01-05 | PXD036243 | Pride
Bacillus anthracis Anthrax Species-specific marker peptides High-resolution mass spectrometry 
ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-08 | PXD003155 | Pride
Spinocerebellar ataxia type 2 (atxn2)  mass spectrometry  proteome profiling  metabolome profiling  multiple reaction monitoring (mrm)  protein - protein interaction network (ppi) analysis  pathway analysis. 
ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084933 | MassIVE
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ?0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080873 | MassIVE
ProteomicsIdentification of X-linked genes that drive sex differences in murine embryonic stem cells
Dosage imbalance of X-chromosomal genes contributes to sex differences, in particular during early development, when both X chromosomes are active in females. X-encoded inhibitors of the differentiation-promoting MAP kinase (MAPK) signalling pathway slow down development, increase levels of naive pl...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD017875 | Pride
Klhl13 Sex differences Pluripotency Differentiation Mapk Mouse embryonic stem cells 
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ρ0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo sapiens (Human) 
2016-02-08 | PXD002425 | Pride
Proteome profiling Ρ0 cells Metabolome profiling Mass spectrometry Ubiquitination Retrograde response Oxphos deficiency 
ProteomicsAn impaired respiratory electron chain triggers retrograde response and de-ubiquitination of solute carrier amino acid transporters
Hundreds of genes have been associated with respiratory chain disease so far. Elimination of the respiratory electron chain by depleting the entire mitochondrial DNA (mtDNA, ��0 cells) has therefore one of the most severe impacts on the energy metabolism in eukaryotic cells. Here, we integrated prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD002270 | Pride
Proteome profiling Ρ0 cells Metabolome profiling Mass spectrometry Ubiquitination Retrograde response Oxphos deficiency 
ProteomicsProteome profilling of chromophobe renal cell carcinomas
LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, nine patients included. The chromophobe renal cell carcinoma cells (UOK276) under different conditions were also analyzed.
ORGANISM(S): Homo sapiens (Human) 
2020-07-23 | PXD019123 | Pride
Chromophobe renal cell carcinomas Proteomics Kidney cancer Proteome 
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