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TranscriptomicsUnique gene program of rat mesenteric arteries as revealed by Deep RNA Sequencing
This study used Deep RNA sequencing to define gene expression in the small resistance arteries and compare to a reference conduit artery, the aorta Methods: Deep RNA Sequencing (~90 million reads) was performed on 2 samples of adult SD rat mesenteric arteries and compared to that of 2 samples of aor...
ORGANISM(S): Rattus norvegicus 
2015-07-13 | E-GEOD-64450 | biostudies-arrayexpress
TranscriptomicsEstrogens and selective estrogen receptor modulators regulate gene and protein expression in the mesenteric arteries
Estrogen is a reproductive steroid hormone that has both beneficial and detrimental effects on the cardiovascular system. Selective estrogen receptor modulators (SERMs) exhibit partial estrogen agonist/antagonist activity in estrogen target tissues. Since we still have an incomplete picture of the ...
ORGANISM(S): Rattus norvegicus 
2011-07-06 | E-GEOD-23037 | biostudies-arrayexpress
ProteomicsEffect of age on the vascular proteome in middle cerebral arteries and small mesenteric arteries in mice
Effect of age on the vascular proteome in middle cerebral arteries and small mesenteric arteries in mice
ORGANISM(S): Mus Musculus (mouse) 
2022-02-09 | PXD024070 | JPOST Repository
TranscriptomicsExpression data from adult mouse mesenteric arteries
Vascular smooth muscle cells require beta1 integrin for survival. Following the induced deletion of smooth muscle beta1 integrin, smooth muscle cells undergo apoptosis and arteries become fibrotic. This microarray study on mesenteric arteries 2 weeks after the initiation of beta1 integrin deletion s...
ORGANISM(S): Mus musculus 
2013-02-26 | E-GEOD-44663 | biostudies-arrayexpress
ProteomicsDeep proteomic analysis of small arteries unravels critical changes associated with early-onset high blood pressure in hypertensive rats
Background: The vascular wall of small arteries is heavily affected by high blood pressure. However, the underlying mechanisms causing vascular changes are not fully elucidated. Using a novel data-independent acquisition mass spectrometry (DIA-MS) approach, we aimed to determine the proteomic change...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-01-06 | PXD026051 | Pride
Mesenteric arteries Rat Hypertension Blood pressure Dia 
ProteomicsMesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
The dynamic nature of the microtubule network is regulated in part by post-translational modifications – particularly through acetylation, which stabilizes the microtubule network. Whether post-translational modifications of the microtubule network in vascular smooth muscle cells contribute to the p...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-02-21 | PXD045602 | Pride
Hypertension Β-adrenoceptor Vasculature Ptm Microtubules Post-translational modification Acetylation Tubulin 
ProteomicsParacetamol metabolism by endothelial cells – potential mechanism underlying intravenous paracetamol-induced hypotension
We have shown previously that a metabolite of acetaminophen (APAP), N-acetyl-p-benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension observed when APAP is administered intravenously. However, it is unknown whether APAP metabolism to NAPQI is possible in the vascul...
ORGANISM(S): Rattus rattus (Black rat) 
2025-05-20 | PXD058085 | Pride
Napqi Acetaminophen Endothelium Cyp20a1 Myeloperoxidase Paracetamol 
TranscriptomicsInterference with PPAR gamma signaling in mesenteric artery
Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset h...
ORGANISM(S): Mus musculus 
2012-09-24 | E-GEOD-36482 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of mesenteric arteries and veins in Crohn's disease compared to controls from non-IBD samples
Histology in the mesentery pointed to altered blood vessels. This experiment was designed to define the differences in gene expression in vessels from Crohn's disease versus controls. Crohn's disease was separately evaluated in inflamed (central disease) areas and in adjacent noninflamed areas. Lase...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66545 | biostudies-arrayexpress
TranscriptomicsExpression data from adult mouse mesenteric arteries
Vascular smooth muscle cells require beta1 integrin for survival. Following the induced deletion of smooth muscle beta1 integrin, smooth muscle cells undergo apoptosis and arteries become fibrotic. This microarray study on mesenteric arteries 2 weeks after the initiation of beta1 integrin deletion s...
ORGANISM(S): Mus musculus 
2013-02-26 | GSE44663 | GEO
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