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ProteomicsMild acid elution and MHC immunoaffinity chromatography reveal similar albeit not identical profiles of the HLA immunopeptidome
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012771 | Pride
Mhc immunoaffinity chromatography Cid Post-translational modification Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012498 | Pride
Post-translational modification Ethcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD or HCD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD012437 | Pride
Post-translational modification Ethcd Hcd Hla ligandome Mild acid elution Cysteinylation Mhc bound peptides 
UnknownMild Acid Elution and MHC Immunoaffinity Chromatography Reveal Similar Albeit Not Identical Profiles of the HLA Class I Immunopeptidome.
Not available
S-EPMC7786382 | biostudies-literature
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-19 | PXD008733 | Pride
Tissue Mass spectrometry Mhc Immunopeptidome Map 
ProteomicsChicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer...
ORGANISM(S): Gallus gallus (Chicken) 
2021-09-10 | PXD023954 | Pride
Mdv Chicken mhc Immunopeptidomics Mhc class ii Ibdv Mhc class i 
ProteomicsMHC immunopeptidome of JY cells analysed by EThcD at Orbitrap Fusion after mild acid elution
To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of key importance. Preceding the analysis by mass spectrometry, MHC peptide ligands are typically isolated by MHC immunoaffinity chromatography...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098363 | MassIVE
ProteomicsCharacterization of I-Ab MHCII immunopeptidome eluted from control and obese (Ob/Ob) mice using a combination of data-dependent (DDA) and data-independent acquisition (DIA) nanoLC mass spectrometry
In Dendritic cells (DC), the MHC II eluted immunopeptidome reflects the antigenic composition of the microenvironment. Proteins are transported and processed into peptides in endosomal MHC II compartments through autophagy or phagocytosis; extracellular peptides can also directly bind MHC II protein...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-21 | PXD023581 | Pride
Mouse dendritic cells  i-ab mhc-ii immunopeptidome  dda and dia nanolcms 
ProteomicsMHC-I peptidome analysis of human cancer cell lines
In this study, we sought to identify naturally presented MHC peptides in 3 human cancer cell lines: A431, Colo668, HuCCT1. Peptides identified were 8-15 amino acid long with the majority between 8 to 11 amino acids which match known properties of MHC-I presented peptides.
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD033685 | Pride
Hla-i Lc-ms/ms 
ProteomicsMHC-I peptidome analysis of human cancer cell lines
In this study, we sought to identify naturally presented MHC peptides in 8 human cancer cell lines: PANC.1, A.375, SW527, CaSki, PC.3, LNCaP_clone_FGC, MCF.7, and VMRC.LCD. Peptides identified were 8-15 amino acid long with the majority between 8 to 11 amino acids which match known properties of MHC...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022020 | Pride
Hla-i Lc-ms/ms 
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