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ProteomicsMultivalent lipid targeting by the calcium-independent C2A domain of Slp-4/granuphilin
Synaptotagmin-like protein 4 (Slp-4), also known as granuphilin, is a Rab effector responsible for docking insulin secretory vesicles to the plasma membrane prior to exocytosis. Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology (SHD) domain, interacts with plasma membrane SNARE comp...
ORGANISM(S): Homo sapiens (Human) 
2020-12-08 | PXD021393 | Pride
Granuphilin Intact protein Phosphogluconate Lcms 
ProteomicsAggrelyte-2 Promotes Protein Solubility and Decreases Stiffness in Lenses through Lysine Acetylation and Disulfide Reduction
Aging proteins in the lens become increasingly aggregated and insoluble, contributing to presbyopia. In this study, we investigated the ability of aggrelyte-2 (N,S-Diacetyl-L-cysteine methyl ester) to reverse the water insolubility of aged human lens proteins and to decrease stiffness in cultured hu...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035049 | Pride
Human Ptm Lens Lysine Eye Acetylation 
ProteomicsGuanine is an inhibitor of c-Jun terminal kinases
We have shown that JNKs are directly inhibited by guanine. We here quantify the proteome and phosphoproteome of mouse embryonic fibroblasts treated with guanine or vehicle.
ORGANISM(S): Mus musculus (Mouse) 
2025-07-02 | PXD062305 | Pride
Mouse Phosphoproteome Embryonic fibroblasts 
ProteomicsQuantifying Protein Acetylation in Diabetic Nephropathy from FFPE Explants
Background: Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of chronic kidney disease and end stage renal disease. One potential mechanism underlying cellular dysfunction contributing to kidney disease is aberrant post-translational modifications, suc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD041884 | Pride
Proteomics Formalin-fixed paraffin-embedded tissue Mass spectrometry Kidney disease Acetylation Diabetes 
ProteomicsQuantifying Competition Among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism
Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-23 | PXD012089 | Pride
Ethanol metabolism Succinylation Mitochondira Acetylation Acylation 
ProteomicsAcetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
In this manuscript we have explored the role of both Nrf2 and NQO1 in protection against diet-induced metabolic syndrome and demonstrate that both Nrf2 and NQO1 provide protection against HFD-induced adverse phenotypes in a mouse model
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015070 | Pride
Nqo1 Mouse Metabolic syndrome Quantitation Acetylomics Skeletal muscle 
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsAcetylation of Proximal Cysteine-Lysine Pairs by Alcohol Metabolism
Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. Combined, these factors alter proteomic and epigenetic marks providing a critical opportunity to identify therapeutic targets. Indeed, alcohol-induced protein acetylation is a...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-17 | PXD054686 | Pride
Alcohol-associated liver disease Protein modeling Mass spectrometry Cysteine proteomics Redox Acetylation 
ProteomicsClick Chemistry-based Thiol Redox Proteomics Reveals Significant Cysteine Reduction Induced by Chronic Ethanol Consumption
In the U.S., alcohol-associated liver disease (ALD) impacts millions of people and is a major healthcare burden. While the pathology of ALD is unmistakable, the molecular mechanisms underlying ethanol hepatotoxicity are not fully understood. Hepatic ethanol metabolism is intimately linked with alte...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-19 | PXD042070 | Pride
Redox proteomics Proteomics Glutathione Mus musculus Agilent 6550 q-tof Redox Cysteine Thiol Click chemistry Alcohol-associated liver disease 
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient for proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead to cell d...
ORGANISM(S): Homo Sapiens 
2026-02-25 | PXD070673 | panorama
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