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ProteomicsIdentification of SART3 as a pre-miR-34a–binding protein
MicroRNAs (miRNAs or miRs) are small, noncoding RNAs that are implicated in the regulation of nearly all biological processes. Global miRNA biogenesis is altered in many cancers and RNA-binding proteins (RBPs) have been shown to play a role in this process, presenting a promising avenue for targetin...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD015278 | Pride
Proteomics Sart3 Mirna Rbps Mir34 
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
ProteomicsPhAXA-MS analysis of 4EBP1, cJun, and ERK2 Kinases
Recent estimates of the human proteome suggest that there are ~20,000 protein-coding genes, the protein products of which contain >145,000 phosphorylation sites. Unfortunately, in-depth examination of the human phosphoproteome has far outpaced the ability to annotate the kinases that mediate these p...
ORGANISM(S): Homo sapiens (Human) 
2019-05-04 | PXD013097 | Pride
Chemoproteomics Cjun 4e-bp1 Erk2 Kinases Activity based probes Crosslinking 
ProteomicsA class of reactive acyl-CoA species reveals the nonenzymatic origins of protein acylation
The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-11 | PXD005895 | Pride
Glutarylation Hmgylation Nonenzymatic protein acylation 
TranscriptomicsmiR-126 governs human leukemia stem cell quiescence and therapeutic resistance
In acute myeloid leukemia (AML), leukemia stem cells (LSC) play a central role in disease progression and recurrence due to their intrinsic capacity for self-renewal and chemotherapy resistance. Whereas epigenetic regulation balances normal blood stem cell self-renewal and fate decisions, mutation a...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-55770 | biostudies-arrayexpress
UnknownUridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes
Not available
S-SCDT-10_1038-S44319-025-00520-7 | biostudies-other
UnknownMechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2
Not available
S-SCDT-EMBOJ-2020-106275 | biostudies-other
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
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