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MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
ProteomicsAn improved capillary isoelectric focusing-mass spectrometry method for characterization of monoclonal antibody charge variants
Here, we improved the stability and enhanced separation resolution of automated cIEF-MS by bettering the quality of capillary neutral coating, reducing catholyte pH to 10 for cIEF-MS for the first time, and systematically optimizing the cIEF separation conditions for characterization of monoclonal a...
ORGANISM(S): Homo sapiens (Human) 
2026-08-19 | PXD082799 | Pride
Monoclonal antibody charge variants Cief-ms 
TranscriptomicsTargetting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or siRNA
CD24 is a potential oncogene reported to be overexpressed in a large variety of human malignancies. We have shown that CD24 is overexpressed in 90% of colorectal tumors at a fairly early stage in the multistep process of carcinogenesis. Anti-CD24 monoclonal antibodies (mAb) induce a significant grow...
ORGANISM(S): Homo sapiens 
2009-03-07 | E-GEOD-15102 | biostudies-arrayexpress
ProteomicsDilute-and-Shoot Analysis of Therapeutic Monoclonal Antibody Variants in Fermentation Broth: A Method Capability Study
Monoclonal antibodies (mAbs) are widely applied as highly specific and efficient thera-peutic agents for various diseases, including cancer, inflammatory and autoimmune diseases. As protein production in cellular systems inherently generates a multitude of molecular variants, manufacturing of mAbs r...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011017 | Pride
Glycation Monoclonal antibodies Process analytical technology Electrospray ionization mass spectrometry Pat Glycosylation Biosimilar Mam Multiple attribute monitoring Antibody subunits Structural analysis Fermentation Process monitoring High-performance liquid chromatography 
ProteomicsThe specificity of the anti-bass IgM monoclonal antibody (mAb) was validated by mass spectrometry.
The specificity of the anti-bass IgM monoclonal antibody (mAb) was rigorously validated by immunoprecipitation coupled with mass spectrometry (IP-MS). This analysis confirmed the mAb’s selective binding to IgM while identifying potential off-target interactions, ensuring its suitability for IgM depl...
ORGANISM(S): Micropterus Salmoides 
2025-05-02 | PXD063688 |
TranscriptomicsEighteen hours monoclonal antibody C7 exposure
We have developed a monoclonal antibody (mAb) C7 that reacts with Als3p and enolase present in Candida albicans cell wall and exerts three anti-Candida activities: candidacidal activity and inhibition of both adhesion and filamentation. To investigate the mode of action of mAb C7 on fungal viability...
ORGANISM(S): Candida albicans 
2010-12-11 | E-GEOD-25969 | biostudies-arrayexpress
TranscriptomicsmRNA expression profile in peripheral blood cells of RA patients following treatment with an anti-TNFa mAb, infliximab
Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-t...
ORGANISM(S): Homo sapiens 
2007-10-09 | E-GEOD-8350 | biostudies-arrayexpress
ProteomicsMass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1
Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb developme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096536 | MassIVE
UnknownCharacterization and Value Assignment of a Monoclonal Antibody Reference Material, NMIJ RM 6208a, AIST-MAB
Not available
S-EPMC9207415 | biostudies-literature
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