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UnknownEpigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients.
Not available
S-EPMC5024692 | biostudies-literature
UnknownDopamine receptor D3 signalling in astrocytes promotes neuroinflammation.
Not available
S-EPMC6896356 | biostudies-literature
UnknownDouble-Framed Thin Elastomer Devices.
Not available
S-EPMC7735669 | biostudies-literature
ProteomicsGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic -cell function and prevent type 2 diabetes (T2D) progre...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-30 | PXD056782 | Pride
Membrane contact sites Pancreatic beta cells Mitochondrial remodelling Akaps Er-mitochondrial contacts Incretins Sphkap Compartmentalised pka signalling Glp-1r Vap-b 
ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 44 identified hits, we found a ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068572 | Pride
Gpx4 Rsl3 Cancer Senescence Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors Chloroacetamides 
UnknownProcesses that drive the population structuring of Jenynsia lineata (Cyprinidontiformes, Anablepidae) in the La Plata Basin.
Not available
S-EPMC8207347 | biostudies-literature
UnknownPrimary ciliary dyskinesia and psychological well-being in adolescence.
Not available
S-EPMC6977723 | biostudies-literature
UnknownActivation of glucagon-like peptide-1 receptors and skilled reach foraging.
Not available
S-EPMC8244104 | biostudies-literature
ProteomicsMolecular analysis of brain tumour models
Pilocytic astrocytomas and other paediatric low-grade gliomas (pLGGs) are often considered single-pathway diseases due to the predominance of MAPK/ERK pathway alterations observed in these patients. However, emerging evidence suggests that the MAPK/ERK interacts within a complex signalling network t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD060246 | Pride
Kiaa1549 Label-free proteomics Mapk Braf Plgg Phosphoproteomics Fgfr Lc-ms/ms 
ProteomicsIntegrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056848 | Pride
3d Chromatin Proteomics Epigenetics Resistance Her2 Lc-ms/ms 
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