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TranscriptomicsLaser Capture Microdissection of Hyperlipidemic Mouse Aorta Atherosclerosis
Atherosclerosis is a transmural chronic inflammatory condition of small and large arteries that is associated with adaptive immune responses at all disease stages. However, impacts of adaptive immune reactions on clinically apparent atherosclerosis such as intima lesion (plaque) rupture, thrombosis,...
ORGANISM(S): Mus musculus 
2011-11-03 | E-GEOD-21419 | biostudies-arrayexpress
ProteomicsAorta proteomic analysis thoracic-abdominal
Aortic aneurysms is increasing as the human population ages. Pathological oxidative stress is implicated in development of aortic aneurysms. We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amin...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD060700 | Pride
Oxidative stress Vascular biology Chemogenetics Aneurysm 
ProteomicsSelective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression
Tumor necrosis factor (TNF) is elevated in human abdominal aortic aneurysms (AAA). Non-selective TNF inhibition has been linked to several severe side effects. Compounds that target the proinflammatory soluble TNF (solTNF) while preserving the immunomodulatory capabilities of transmembrane TNF (tmTN...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD035178 | Pride
Mouse abdominal aorta aneurysm 
TranscriptomicsTranscription profiling of aorta from mice underexpressing Fibulin-4 to investigate its role in elastic fibre assembly and cardio-vasuclar disease
Extracellular elastic fibres apply structure and mechanical elasticity to organs such as large arteries, lungs and skin 1. Elastic fibres are assembled through polymerization of tropoelastin monomers and loss of elastin is associated with aneurysmal degeneration of the aorta 2. The Fibulins are a ...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-840 | biostudies-arrayexpress
ProteomicsSoluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation
The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme and pharmacological inhibition of sEH was shown to protect against various inflammatory ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD073197 | Pride
Angiotensin ii Calcium chloride Liver Soluble epoxide hydrolase Abdominal aortic aneurysm 
ProteomicsMouse and human abdominal aneurysm proteomics
Aortic tissues of developing and established aneurysms produced by angiotensin II (AngII) infusion were examined in Apoe-/- and Ldlr-/- mice. Aortas were also acquired from wildtype C57BL/6J mice following intraluminal elastase incubation. Aortas were dissected free and separated into eight anatom...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-02 | PXD032293 | Pride
Fermt3 Co-regulation Mass spectrometry 
TranscriptomicsMurine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7
Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this m...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-51227 | biostudies-arrayexpress
ProteomicsShotgun LC-MS analysis of aorta and liver tissues from WT and Gal-1 KO mice to study the role of Galectin-1 in vascular remodeling in atherosclerosis and abdominal aortic aneurysm
Pathological vascular remodeling is the underlying cause of main cardiovascular diseases (CVD) including atherosclerosis and abdominal aortic aneurysm (AAA). We analyzed the potential role of galectin-1 (Gal-1) in atherosclerosis and AAA. Atherosclerosis was induced in mice lacking Gal-1 (Lgals1-/-)...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD024637 | Pride
Lc-ms Mouse Liver Aorta 
TranscriptomicsMicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-2...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-32937 | biostudies-arrayexpress
ProteomicsProteomics analysis of mouse aorta samples
Proteomics analysis of mouse abdominal aorta were performed. The oxidation of hemoglobin was investigated.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-10-14 | MSV000099478 | MassIVE
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