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ProteomicsSkeletal Muscle from Mice fed with HFD LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017683 | Pride
Mouse skeletal muscle hfd 
ProteomicsqXL-MS of insulin resistance in mouse skeletal muscle
We established a whole tissue qXL-MS workflow to investigate proteome-wide changes in protein:protein interactions in mouse skeletal muscle insulin resistance (IR). Mice were feed a standard chow diet or a high fat diet (HFD) for 12 weeks which induced skeletal muscle insulin resistance. The Extenso...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077541 | Pride
Mouse skeletal muscle Insulin resistance 
TranscriptomicsTranscription profiling of liver, skeletal muscle and white adipose tissue from ApoE3L mice
Our aim was to investigate gene expression changes over time in liver of ApOE3*Leiden mice on a high-fat diet. Probesets were remapped and annotated into Entrez gene-ids using the custom MBNI CDF-file, version 9.0.1 - the GCRMA data generated
ORGANISM(S): Mus musculus 
2010-07-28 | E-TABM-1039 | biostudies-arrayexpress
TranscriptomicsA high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome
An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular dis...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17576 | biostudies-arrayexpress
TranscriptomicsHoxd genes and fiber type-specific markers specify adult mouse muscle type in a diet-independent way
Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are ident...
ORGANISM(S): Mus musculus 
2010-09-03 | E-GEOD-18127 | biostudies-arrayexpress
GenomicsMouse HFD Liver Skeletal Muscle SLC16A13 Knock-Out
Mouse HFD Liver Skeletal Muscle SLC16A13 Knock-Out
PRJNA641022 | ENA
ProteomicsAcetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
In this manuscript we have explored the role of both Nrf2 and NQO1 in protection against diet-induced metabolic syndrome and demonstrate that both Nrf2 and NQO1 provide protection against HFD-induced adverse phenotypes in a mouse model
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015070 | Pride
Nqo1 Mouse Metabolic syndrome Quantitation Acetylomics Skeletal muscle 
ProteomicsCysteine Redox proteomics of PDIA6 over-expressing skeletal muscle
To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD075204 | Pride
Pdia6 Iodo-tmt 
TranscriptomicsAffymetrix GeneChip Mouse Gene 1.0 arrays of RNA extracted from gastrocnemius muscle of 4 global Ppp3cb KO mice and 4 corresponding WT littermates, and 4 skeletal muscle-specific Ppp3r1Mlc1fCre KO and 4 corresponding WT littermates.
Global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle but not adipose tissue or liver led to protection from high-fat diet induced obesity and comorbid sequelæ. Ser637 hyperphosphorylation of dynamin-related protein 1 (Drp1) in ...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-71174 | biostudies-arrayexpress
ProteomicsExtracellular Vesicles from Adiponectin-Deficient Mice Mediate Skeletal Muscle Metabolic Dysfunction and Insulin Resistance
Adiponectin regulates systemic metabolism and enhances extracellular vesicle (EV) biogenesis, but the impact of adiponectin deficiency on circulating EV composition and their impact on muscle metabolism remains unclear. Here, we integrated proteomic analyses of plasma EVs from wild-type (WT) and adi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-08-03 | PXD070917 | Pride
Metabolism Adiponectin Proteomics Extracellular vesicles Skeletal muscle 
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