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ProteomicsProteogenomic analysis of Helicobacter pylori strain 26695
Dear Sir or Madam, we report an in-depth proteogenomics study of Helicobacter pylori strain 26695 and provide the supporting MS data via ProteomExchange. The study includes 2 biological replicates with 6 different datasets: G1: in-gel digestion with trypsin, replicate 1 G2: in-gel digestion with t...
ORGANISM(S): Helicobacter pylori 26695 
2013-08-01 | PXD000054 | Pride
Ltq orbitrap Proteogenomics Signal peptide Coding sequence Proteomics Helicobacter pylori strain 
ProteomicsStable isotope labeling by amino acids in cell culture based proteomics reveals differences in protein abundances between spiral and coccoid forms of the gastric pathogen Helicobacter pylori
Helicobacter pylori (H. pylori) is a ε-proteobacterium that colonizes the stomach of about half of the world's population. Persistent infections have been associated with several gastric diseases. Mainly rod- or spiral shaped but also coccoid H. pylori forms have been isolated from mucus layer biops...
ORGANISM(S): Helicobacter pylori 26695 
2017-11-24 | PXD008284 | Pride
Helicobacter pylori Silac 
ProteomicsSoluble VCAM-1 may serve as a pharmacodynamic CSF marker to monitor BACE2 activity in non-human primates
The beta-secretase beta-site APP cleaving enzyme 1 (BACE1) is a major drug target for Alzheimer’s disease (AD). Clinically tested BACE1 inhibitors induced unexpected cognitive side effects that may stem from their cross-inhibition of the homologous protease BACE2. Yet, little is known about BACE2 fu...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-07-16 | PXD056159 | Pride
Dia Cerebrospinal fluid Alzheimer's disease Csf Bace1 Macaca fascicularis Labelfree Vcam1 
ProteomicsProteomics of tumor associated microglia, tumor tissue from SB28 glioblastoma mice, and control microglia
The 18 kDa translocator protein (TSPO) emerges as an important PET biomarker to assess the tumor microenvironment (TME) in glioblastoma. However, various cellular sources hamper interpretation and biological understanding of TSPO and other immune biomarkers in the TME. Thus, we established a novel m...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-30 | PXD044033 | Pride
Tumor tissue Microglia Tumor associated microglia Sb28 glioblastoma 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-15 | PXD055223 | Pride
Adam17 Ectodomain shedding Mouse Hepsec Secretome Metalloproteases 
ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
ProteomicsProteomic analysis of monocyte derived macrophages from Niemann-Pick disease type C patients
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in Npc1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain uncharacterized...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD020659 | Pride
Npc Macrophage Lysosomal storage disorder 
ProteomicsProteomic signature of NPC1 KO microglia
Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder mainly caused by autosomal recessive mutations in Npc1 which result in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is one of the prominent pathological features, consequences of NPC1 loss on microglial ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD019447 | Pride
Npc1 Niemann-pick disease Microglia Neurodegeneration 
ProteomicsProteomics of cerebrospinal fluid (CSF) of acitretin treated patients
Acitretin has been shown to increase ADAM10 expression. In a phase II clinical trial, Alzheimer's disease patients were treated with acitretin or placebo to increase ADAM10 levels to counteract amyloid beta production. Analysis of the cerebrospinal fluid of from 18 AD patients treated with the synth...
ORGANISM(S): Homo sapiens (Human) 
2019-04-06 | PXD010756 | Pride
Alzheimer disease Csf Acitretin 
ProteomicsProteome analysis of brain microvessels from htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathyis) a small-vessel disease caused by loss of function mutaions of htrA1, which cleaves several extracellular matrix proteins. Here, we isolated microvessels from htra1 KO and wild type control mice to...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-03 | PXD009411 | Pride
Small vessel disease Microvessel Carasil 
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