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UnknownMulti-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Not available
S-EPMC4872014 | biostudies-literature
ProteomicsIdentification of substrates of the CRL4-HBx E3 ubiquitin ligase
Hepatitis B Virus (HBV) remains a major public health problem, and is a major cause liver cancer worldwide. HBV infection in vivo requires the function of the HBx protein, which facilitates expression of viral genes from the episomal genome by an unknown mechanism. Evidence suggests that HBx funct...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004762 | Pride
Ubiquitylation Hbv Crl4 Cullin Substrate Hbx Mln4924 
ProteomicsNovel non-canonical role of STAT1 in Natural Killer cell cytotoxicity
STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences of Stat1-deficiency have been described in detail the underlying molecular functions of STAT1 in NK cells are only partially understood. Here we describe a novel non-canonical role of STAT1 that was unm...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-07 | PXD002206 | Pride
Immunological synapse Vesicle F-actin Proteome Interactome 
ProteomicsCalmodulin and CHK2 kinase crosslinking
Recombinant proteins were mixed and then crosslinked either with DMTMM or by SDA and UV exposure. Complexes were resolved by SDS-PAGE, excised and tryptic peptides identified by MS.
ORGANISM(S): Homo Sapiens (human) 
2026-03-28 | PXD062332 | JPOST Repository
TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
ProteomicsAnalysis of ZNF827 Halotag pulldown for a manuscript titled ‘ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway’
Mass spectrometry analysis of ZNF827 Halotag pulldown ZNF827 pull-downs were performed in HEK 293T cells overexpressing HaloTag ZNF827 or empty vector control using the HaloTag® Protein Pull-Down and Labelling System (Promega) according to the manufacturer’s protocol. Pull-downs were subjected mass ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050191 | Pride
Atr Ssdna Znf827 Dna damage response 
UnknownGenetic variants in root architecture-related genes in a Glycine soja accession, a potential resource to improve cultivated soybean.
Not available
S-EPMC4354765 | biostudies-literature
TranscriptomicsMurine Microglial Gene Expression after Abdominal Sepsis
Mice underwent cecal ligation and puncture (19 GA with concurrent administration of imipenem), sham operation, or were unoperated. 14 days after operation, microglia were isolated by fluorescent activated cell sorting for CD11b+/CD45mid/CD64+ cells. For each sample, the brains of 3 mice were poole...
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-4180 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling upon knockdown of the RNA-binding protein Unkempt
RNAseq to assess changes in transcript abundance upon knockdown of the RNA-binding protein Unkempt in human SH-SY5Y cell lines.
ORGANISM(S): Homo sapiens 
2015-01-15 | E-MTAB-2277 | biostudies-arrayexpress
TranscriptomicsBaseline expression from transcriptional profiling of zebrafish developmental stages
Establish baseline expression transcriptional signatures for zebrafish developmental stages. Total RNA was extracted from single wild type zebrafish embryos at a series of different developmental stages. RNA from 12 embryos was pooled to generate a replicate.The RNA was DNase treated. Stranded RNAs...
ORGANISM(S): Danio rerio 
2016-06-12 | E-ERAD-475 | biostudies-arrayexpress
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