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TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress
ProteomicsMyelin proteome differences in old and young mice
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is a central component in maintaining physiological peripheral nerve function, and dif...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-19 | PXD040719 | Pride
Myelin Peripheral nervous system Neuropathy 
ProteomicsProteome profile of myelin in the zebrafish brain
While the myelin proteome is well characterized in mice, much less is known about the protein composition of myelin in non-mammalian species such as zebrafish (Danio rerio), despite its increasing popularity as model organism for myelin biology. Here, we assess the proteome of myelin biochemically p...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-03-22 | PXD023037 | Pride
Transcriptome Oligodendrocyte Mbp Label-free proteomics Teleost Cd59 Central nervous system (cns) Mpz Danio rerio Plp Zebrafish Myelin proteome 
ProteomicsThe CNS myelin proteome: Deep profile and persistence after post-mortem delay
We revisited the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. A data-independent acquisition (DIA) workflow with alternating low and elevated energy (MSE) provided the h...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-16 | PXD020007 | Pride
Mass spectrometry Oligodendrocyte Proteolipid protein (plp) Central nervous system (cns) Label-free proteomics Myelin basic protein (mbp) Post mortem-delay Cyclic nucleotide phosphodiesterase (cnp) Myelin proteome Transcriptome Demyelination Autopsy 
ProteomicsMyelin proteome alterations upon oligodendroglial deletion of CDC42 and its effector proteins CDC42EP1/CDC42EP2
The regular structure of healthy CNS myelin sheaths requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. Their assembly scaffolds the innermost non-compacted myelin layer as a late step of CNS myelin maturation and their di...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-30 | PXD066943 | Pride
Label-free protein quantification White matter Cytoskeleton Oligodendrocyte Septins Mass spectrometry Myelination Myelin pathology Myelin proteome 
ProteomicsConservation and divergence of myelin proteome profiles between humans and mice
While myelin is commonly assessed in mice as a model for humans, it remained unclear to which extent their myelin protein composition is similar. We analyzed the proteome of myelin biochemically purified from human white matter by two steps of discontinuous sucrose density gradient centrifugation in...
ORGANISM(S): Homo sapiens (Human) 
2022-05-16 | PXD029727 | Pride
Oligodendrocyte Human post mortem brain tissue Label-free proteomics Mass spectrometry Central nervous system (cns) Autopsy Myelin proteome Translation 
ProteomicsProteome profile of peripheral myelin in healthy mice and in a neuropathy model
Using the sciatic nerve as a model, we biochemically purified peripheral nervous system (PNS) myelin and systematically assessed its proteome by dedicated, partly ion mobility-enhanced data-independent acquisition (DIA) workflows with alternating low and elevated energy (MSE) modes. Specifically, we...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-20 | PXD015960 | Pride
Transcriptome Axon degeneration Mouse Dynamic range enhancement Peripheral nervous system (pns) Charcot-marie-tooth disease Label-free quantification Myelin proteome Neuropathy Demyelination 
ProteomicsDevelopmental maturation but no sex-dependent divergence of the murine CNS myelin proteome
To assess whether the CNS myelin proteome varies within the same species, we used quantitative mass spectrometry to compare myelin purified from mouse brains at three developmental timepoints (P18, P75, 6 months), brains of male and female mice, and four CNS regions (cortex, corpus callosum, optic n...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD053062 | Pride
Axon/glia-interaction Label-free protein quantification White matter Mass spectrometry Myelin maturation Oligodendrocyte Central nervous system (cns) Myelin proteome 
ProteomicsProgressive axonopathy when oligodendrocytes lack the myelin protein CMTM5
Chemokine-like factor-like MARVEL-transmembrane domain containing protein 5 (CMTM5) is a tetraspan-transmembrane protein highly enriched in oligodendrocytes and central nervous system (CNS) myelin. We analyzed the proteome of myelin biochemically purified from mouse brains upon genetic disruption of...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD029443 | Pride
Chemokine-like factor-like marvel-transmembrane domain containing protein (cmtm) family Oligodendrocyte Label-free proteomics Mass spectrometry Central nervous system (cns) Wallerian degeneration Neurodegeneration Myelin proteome 
ProteomicsAltered turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of 2-hydroxylated fatty acids, which are a building block of sphingolipids. This 2-hydroxylated sphingolipids can be found in various tissues such as brain, spinal cord, skin, testis, ovary, kidney, stomach, or intestine with a notably...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021021 | Pride
Cns Mice Hereditary spastic paraplegia 35 Sphingolipids Neurodegeneration Disease model Fa2h Tmt Time course Myelin Fatty acid hydroxylation Isobaric labeling Fatty acid 2-hydroxylase Opalin 
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