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ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038113 | Pride
Proteomics Lc-ms Tmt 
UnknownNascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.
Not available
S-EPMC4283098 | biostudies-literature
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038376 | Pride
Tmt Proteomics 
ProteomicsNascent RNA antagonises the interaction of regulatory proteins with chromatin
A number of transcriptional and chromatin regulatory proteins have been reported to be recruited to chromatin by specific regulatory RNAs. Whether RNA has a more general role in the interaction of proteins with chromatin is unknown. We used proteomics methods to determine the global impact of nascen...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-15 | PXD018706 | Pride
Rna Regulatory proteins Chromatin 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035489 | Pride
Chromatin Dna repair Access to dna Cell cycle Restoration Heterochromatin Euchromatin Transcription factors Dna replication Propagation 
ProteomicsChromatin proteomics experiments for ProteomeHD
These is a collection of chromatin proteomics experiments that make up the 80 "in-house" biological conditions covered by ProteomeHD (see publication for more details). All experiments use SILAC, resulting in 80 SILAC ratios comparing the impact of various drugs (estradiol, TSA, hydroxytamoxifen, et...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD008888 | Pride
Ncc Chep Proteomehd Silac Chromatin proteomics 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD036236 | Pride
Tmt Proteomics 
ProteomicsAnalysis of histone PTMs in nascent chromatin in new and old histones upon DNA damage (CAL353, CAL358) using the NCC-SILAC approach
Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are assumed to have a causal role in establishing distinct chromatin structures. However, it remains unknown how specific histone PTMs are regulated at brok...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD018220 | Pride
Ncc Histone ptms Silac Camptothecin Replication 
UnknownaniFOUND: analysing the associated proteome and genomic landscape of the repaired nascent non-replicative chromatin.
Not available
S-EPMC8216468 | biostudies-literature
ProteomicsTwo distinct modes for propagation of histone PTMs across the cell cycle
Epigenetic states defined by chromatin can be maintained through mitotic cell division. However, it remains unknown how histone-based information is transmitted. Here we combine nascent chromatin capture (NCC) and triple-SILAC labelling to track histone modifications and histone variants during DNA ...
ORGANISM(S): Homo sapiens (Human) 
2015-03-30 | PXD001980 | Pride
Ncc  histone modifications  inheritance  chromatin  epigenetics 
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