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TranscriptomicsUC San Diego Friedmann Kang Neuronal Differentiation DSD3 SNM
The gene expression pattern of spherical neural masses (SNM) derived from HPRT knockdown murine D3 stem cells during neuronal differentiation to final neurons was invesitigated by RNA-Seq based gene expression analysis and the results were interpreted by GO, GSEA and signaling pathway analyses with ...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-42662 | biostudies-arrayexpress
TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-03-07 | PXD027191 | Pride
Neuronal differentiation Protein complexes Paralogs 
TranscriptomicsMicroarray profiling of mESCs differentiation time course toward neuronal lineage
mESC adapted to 2i/LIF conditions over four passages (8 days) before differentiation towards the neuronal lineage was induced using experimental conditions described in the literature (PMID: 12524553).
ORGANISM(S): Mus musculus 
2017-09-27 | E-MTAB-5861 | biostudies-arrayexpress
ProteomicsSystematic evaluation of morphological and molecular changes in SH-SY5Y cells induced by common differentiation protocols with a particular focus on the abundance of neuronal subtypes
The SH-SY5Y cell line is a triple-cloned subline of SK-N-SH cells that were originally isolated in the early 1970s from a bone marrow biopsy of a four-year-old female patient suffering from neuroblastoma. Since then, this cell line has been used as one of the major cell culture models in neuroscienc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064335 | Pride
Sh-sy5y Proteomics Mass spectrometry Differentiation Neuronal subtype 
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
TranscriptomicsIdentification of a neuronal gene expression signature: Role of cell-cycle arrest in murine neuronal differentiation in vitro
Stem cells are a potential key strategy for treating neurodegenerative diseases in which the generation of new neurons is critical. A better understanding of the characteristics and molecular properties of neural stem cells (NSC) and differentiated neurons can help in assessing neuronal maturity and...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-24116 | biostudies-arrayexpress
ProteomicsCharacterization of Non-histone Lysine Methylation Across Neuronal Differentiation of LUHMES
Over one-third of human lysine methyltransferases (KMTs) and lysine demethylases (KDMs), the enzymes responsible for adding or removing methylation on lysine residues within proteins, are linked to neurodevelopmental disorders (NDDs). Consequently, several studies have explored the roles of specific...
ORGANISM(S): Homo sapiens (Human) 
2026-10-02 | PXD069591 | Pride
Neuronal differentiation Luhmes Lysine methylation 
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD027195 | Pride
Neuronal differentiation Protein complexes Mouse Paralogs 
ProteomicsNeuronal differentiation requires BRAT1 complex to remove REST from chromatin
Repressor element-1 silencing transcription factor (REST) is required for mature neurons formation. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST-mediated silencing of key neurogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050622 | Pride
Integrator Neuronal differentiation Brat1 
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