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ProteomicsA protein microarray-based analysis of S-nitrosylation
Yeast protein microarrays were utilized to investigate determinants of S-nitrosylation by biologically relevant low-mass S-nitrosothiols (SNOs). Large numbers of S-nitrosylated yeast proteins were identified after treatment with SNOs, among which those with active-site Cys thiols residing at N termi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-19218 | biostudies-arrayexpress
MetabolomicsCrosstalk between S-nitrosylation and glycation defines a novel metabolic vulnerability in liver and renal cancers

Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic f...

2026-07-10 | MTBLS15003 | MetaboLights
ProteomicsExperiment of proteomics and S-nitrosylation modifications proteomics in the hearts of HFpEF mice
We established a mouse model of HFpEF using 8-12-week-old male C57BL/6J mice, and conducted proteomic and nitrosylation modification profiling on the hearts of the control group (n=5) and the HFpEF mice (n=5) to determine the phenotypic changes.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD075362 | Pride
Hfpef Heart S-nitrosylation Mouse Post-translational modification Proteomics Lc-ms/ms 
ProteomicsS-nitrosylation of p53 in A375 cells
Nitric oxide (NO) is a pleiotropic signaling molecule that affects numerous biological functions. One unique posttranslational modification of proteins by NO is termed S-nitrosylation (SNO), but the role in modulating key proteins’ function in melanoma has not been fully characterized. In the presen...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD031807 | Pride
A375 Mass spectrometry S-nitrosylation P53 Melanoma cells 
ProteomicsGlobal proteome-wide analysis of cysteine S-nitrosylation in Toxoplasma gondii
Toxoplasma gondii transmitted via various route and rapidly duplicated during the acute infection, which caused the important zoonosis regarding to medicine and veterinary, toxoplasmosis. T. gondii possessed innate capability of producing nitric oxide (NO) and nitric oxide derivatives and S-nitrosyl...
ORGANISM(S): Toxoplasma gondii 
2024-01-26 | PXD046083 | Pride
Toxoplasma gondii  post-translational modifications  cysteine s-nitrosylation  s-nitrosylated pro-teome 
ProteomicsNitrosylation-mediated regulation of MEK-ERK signaling in the NRAS-mutant melanoma
NRAS activating mutations occur in 15-25% of melanoma patients. However, this subtype is more aggressive and refractory to current treatment modalities, including targeted MEK inhibitors, immunotherapies, and the recently emerging RAS inhibitors. Accordingly, identifying novel therapeutic targets an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD050244 | Pride
Nitrosylation Signaling Cancer Melanoma Map kinase 
ProteomicsS-nitrosylation in Chlamydomonas reinhardtii
Protein S-nitrosylation, a post-translational modification consisting in the covalent binding of nitric oxide (NO) to a cysteine thiol moiety, plays a major role in cell signaling and is recognized to be involved in numerous physiological processes and diseases in mammals. The importance of nitrosyl...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-12-19 | PXD000569 | Pride
Nitrosylation  nitric oxide  nitrosoglutathione  chlamydomonas reinhardtii  proteomics  biotin-switch  snosid 
ProteomicsS-nitrosylation in zebra fish tissue regeneration
we found that inducible nitric oxide synthase (iNOS) is critical to this process by virtue of its ability to induce post-translational S-nitrosylation of epigenetic enzymes. The possible link between induction of PSC, S-nitrosylation and tissue regeneration remains largely unexplored. Here, we show ...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) 
2020-03-04 | MSV000085055 | MassIVE
ProteomicsCysteine nitrosylation analysis in SH-SY5Y cells
Cysteine nitrosylation is emerging as important player in cellular signaling and redox homeostasis. Here we applied Cys-BOOST for quantitative analysis of nitrosylated cysteine in SNAP-treated and non-treated SH-SY5Y human neuroblastoma cells.
ORGANISM(S): Homo sapiens (Human) 
2019-05-21 | PXD012485 | Pride
Cysteine Nitrosylation Neuroblastoma cells 
TranscriptomicsIdentification of genes induced on nitrate, role of OxyR
The study aimed to identify role of OxyR during growth on different electron acceptors when E. coli are growing anaerobically. Wt and OxyR null cells were grown on nitrate and fumarate medium anaerobically. Each condition was done in duplicate. RNA was extracted using Qiagen RNeasy kit after stabili...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-05-02 | E-GEOD-24524 | biostudies-arrayexpress
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