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TranscriptomicsTranscription profiling of mouse hippocampus after maternal treatment with saline or 20 mg/kg cocaine twice daily on gestational days 8-19
We explored the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. These data were used as preliminary results for paper:; Maternal cocaine administration in mice alters DNA methy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6651 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from animals treated with cocaine vs controls
Several recent reports show that the cerebral cortex in humans and animals with altered expressions of Wnt/cadherin network-associate molecules display cytoarchitectural abnormalities reminiscent of cortical dysplasias seen in some (mouse-, rat-, and monkey-based) animal models of prenatal cocaine e...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6628 | biostudies-arrayexpress
TranscriptomicsWhole Genome array hippocampus_cocaine
We explored the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. These data were used as preliminary results for paper: Maternal cocaine administration in mice alters DNA methylat...
ORGANISM(S): Mus musculus 
2007-01-09 | GSE6651 | GEO
ProteomicsThe Study of ATRA-Induced Differentiation of the HL-60 Cell Line
Shotgun mass-spectrometric experiment was performed with HL-60 cells induced to differentiation at 0, 3, 24, 48 and 96h after ATRA treatment. Obtained data has been used for label-free quantification by SPIRE platform based on spectral count. Results on proteome profiling were used for up-stream reg...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD006768 | Pride
Proteomics Atra Time-course study Differentiation Hl60 cell line 
ProteomicsNuclear proteomics of induced granulocytic differentiation
The nuclear proteome harbors a sheer number of regulatory proteins, including transcription factors (TFs). Profiling of nuclear proteome during all-trans-retinoid acid(ATRA)-induced differentiation of HL60 cells allows to unveil molecular mechanisms of granulocytic maturation. It is especially impor...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035281 | Pride
Atra Tmt Hl60 Nuclei Proteome 
ProteomicsProteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment
Searching for new strategies of acute myeloid leukemia (AML) treatment is of particular interest. Cell lines, e. g. HL-60 and NB4, represent model systems to study molecular features of leukemic cells. The all-trans-retinoic acid (ATRA) has proven itself to be an effective treatment for one of AML s...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050317 | Pride
Nb4 cell line K562 cell line Atra Tmt labeling Time-course experiment Hl-60 cell line Proteome 
ProteomicsMass-spectrometry analysis of secretome and extracellular vesicles derived from lung and colorectal cell lines
We conducted a proteomic analysis of secretome and EV samples isolated from the conditioned medium of lung cancer LC (A549, NCI-H23, and NCI-H460) and CRC (Caco2, HCT116, and HT-29) cell line models.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057205 | Pride
Caco2 And ht-29 cell lines Hct116 Nci-h460 Extracellular vesicles A549 Nci-h23 Lung cancer Secretome Colorectal cancer 
ProteomicsProteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines:extracellular vesicles only
The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screenin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020467 | Pride
Extracellular vesicles  exosomes  proteomics  mass-spectrometry  colon cancer  lung cancer  biomarkers 
ProteomicsProteomic approach for searching of universal, tissue-specific and line-specific markers of extracellular vesicles in lung and colorectal adenocarcinoma cell lines: whole cell lysate vs. extracellular vesicles
The efficiency of anticancer therapy depends heavily on the molecular features of the tumor. Since tumor-derived extracellular vesicles, including exosomes, contain proteins that are characteristic for producer cells and could be detected in biological fluids, they are of great interest for screenin...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020454 | Pride
Extracellular vesicles  exosomes  proteomics  mass-spectrometry  colon cancer  lung cancer  biomarkers 
ProteomicsShotgun mass-spectrometry of HL-60 cell proteins for spectrum library development
ATRA-induced differentiation of HL-60 cells was studied using targeted mass-spectrometry including selected reaction monitoring (SRM) and parallel reaction monitoring (PRM) approach. PRM experiment was performed in time-course manner, without peptide standards usage. PRM data was inspected in Skylin...
ORGANISM(S): Homo sapiens (Human) 
2017-11-09 | PXD006421 | Pride
Orbitrap velos Atra Differentiation Hl-60 cell line 
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