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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsThe nuclear actin-related protein Arp6 contributes to the radial positioning of chromosome territories.
The chromatin of individual chromosomes is organized into chromosome territories (CTs) in the interphase nucleus. The spatial arrangement of CTs is non-random and evolutionarily conserved. The gene-dense and gene-poor CTs are positioned in the nuclear center and periphery, respectively. As candidate...
ORGANISM(S): Gallus gallus 
2015-11-04 | E-GEOD-14220 | biostudies-arrayexpress
GenomicsNuclear actin is required for transcription during Drosophila oogenesis [RNA-seq]
Nuclear actin is required for transcription during Drosophila oogenesis [RNA-seq]
PRJNA478255 | ENA
GenomicsRegulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation
Regulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation
PRJNA852177 | ENA
GenomicsNuclear actin is required for transcription during Drosophila oogenesis [ChIP-seq]
Nuclear actin is required for transcription during Drosophila oogenesis [ChIP-seq]
PRJNA478251 | ENA
ProteomicsNuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness (part 2: Surface and Nuclear Proteomes)
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scattering and invasion. The endosomal system influences how RTK sign...
ORGANISM(S): Homo sapiens (Human) 
2021-09-28 | PXD027268 | Pride
Invasiveness Serum-response factor (srf) Cell:cell repulsion Epha2 Heptocyte growth factor (hgf) Rab17 Surface and nuclear proteome Actin polymerisation Myocardin-related transcription factor (mrtf) Nuclear g-actin Nuclear import Pancreatic adenocarcinoma (pdac) 
ProteomicsRASSF1A IS REQUIRED FOR THE MAINTENANCE OF NUCLEAR ACTIN LEVELS
Nuclear actin participates in many essential cellular processes including gene transcription, chromatic remodelling and mRNA processing. Actin shuttles into and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD011517 | Pride
Nuclear actin Nucleocytoplasmic shuttling Mst2 Nuclear envelope Rassf1a Exportin-6 Nuclear export Srf Mrtf-a 
GenomicsNuclear actin structure regulates chromatin accessibility [RNA-seq]
Nuclear actin structure regulates chromatin accessibility [RNA-seq]
PRJNA1015598 | ENA
GenomicsNuclear actin structure regulates chromatin accessibility [ATAC-seq]
Nuclear actin structure regulates chromatin accessibility [ATAC-seq]
PRJNA1015599 | ENA
TranscriptomicsExpression in arp6 and swr1 deletion mutants
Actin-related proteins are ubiquitous components of chromatin remodelers, and are conserved from yeast to man. We have examined the role of the budding yeast actin-related protein Arp6 in gene expression, both as a component of the SWR1 complex (SWR-C) and in its absence. We mapped Arp6-binding site...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-01 | E-GEOD-17780 | biostudies-arrayexpress
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