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Proteomics,MultiomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080762 | MassIVE
ProteomicsMouse embryonic stem cell phosphoproteome
Erk-driven differentiation of mouse embryonic stem cells
ORGANISM(S): Mus musculus (Mouse) 
2019-10-22 | PXD008964 | Pride
Erk Phosphoproteomics Lineage priming Msc 
ProteomicsQuantitative metaproteomics of medieval dental calculus reveals individual oral health status
The composition of the ancient oral microbiome has recently become possible to investigate by using advanced biomolecular methods such as metagenomics and metaproteomics. This study presents a look at the individuality of the metaproteomes from 22 medieval Danish dental calculus samples. The proteom...
ORGANISM(S): Homo sapiens (Human) 
2018-11-26 | PXD008601 | Pride
Metaproteomics Calculus 
ProteomicsMetaproteomic profiling of saliva in subjects with periodontitis, dental caries and orally healthy controls
The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. Thus, the purpose of the present investigation was to compare metaproteomic profiles of saliva in oral health and disease. Stimulated saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080763 | MassIVE
ProteomicsProteomics analysis of synergistic drug combination of midostaurin and BMS-754807 in Ewing sarcoma ASP14 cell line
We used quantitative mass spectrometry-based proteomics to unravel global changes in the phosphoproteome upon treatment of ASP14 cells (a Ewing Sarcoma cell line) according to the setup below. The combination of drugs were experimentally shown to infer synergy in terms of cell killing. Three experim...
ORGANISM(S): Homo sapiens (Human) 
2017-04-19 | PXD002765 | Pride
Human Lc-msms Drug synergy Ewing sarcoma 
ProteomicsHigher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer-300-500 SPD
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitivity, and scalability for analyzing large sample cohorts. The...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD066718 | Pride
300spd 500spd 
ProteomicsHigher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer -Tritation Injection time-Astral-zoom
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technologies face limitations in speed, sensitivity, and scalability for analyzing large sample cohorts. The...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD066924 | Pride
Dia 300 spd Injection time 
ProteomicsmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signaling in human colorectal adenocarcinoma cells
Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major unsolved problem. Consequently, predictive markers and a better understanding of resistance mechanisms are urgently needed. To investigate if the recently identified predictive miR-625-3p is functionally involved in oxPt resistance...
ORGANISM(S): Homo sapiens (Human) 
2016-08-12 | PXD002172 | Pride
Kf 
ProteomicsDeep plasma proteome profiling by enrichment of extracellular vesicles
This work show that enrichment of extracellular vesicles by ultracentrifugation increases the plasma proteome depth by an order of magnitude. Following the enrichment protocol, more than two thousand proteins can routinely be quantified reproducibly by label-free quantification and data independent ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-04 | PXD037340 | Pride
Mass spectrometry Plasma proteomics Extracellular vesicles Ultracentrifugation Data independent acquisition Biomarkers 
ProteomicsTowards sensitive, streamlined high throughput protein thermal stability analysis for low sample input
This method development aims to enhance and streamline excisting PISA workflows by reducing pipetting steps and digestion method. With this workflow we want to provide a method with higher reproducibility and simplicity. This method combines the excisting OneTip protocol with low cell concentration ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD056894 | Pride
Lc-ms Onetip Method development Proteomics Pisa 
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