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TranscriptomicsComprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination (RNA-Seq of differentiated NSC after lnc-OPC knockdown)
To quantitative analysis of transcriptome changes caused by lnc-OPC knockdown during OPC differentiation from NSC, lentivirus-based short hairpin RNAs were used to knockdown the lnc-OPC expression in a neural stem cell culture . Subsequently, puromycin-selected NSCs were differentiated to OPC in cul...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74647 | biostudies-arrayexpress
ProteomicsImpact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron
FGF-2 is an important protein involved in a vast number of molecular pathways and a number of cellular functions including glial cell differentiation and response to axon injury. This protein was found to be present significantly in supernatants of female derived murine oligodendrocyte progenitor ce...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD060285 | Pride
Human neural progenitor cell line Rencell vm Opc cell culture supernatant Fgf-2 Secretome lc-ms/ms 
ProteomicsLPC 18:1 protein interaction (OPC)
Oligodendrocyte progenitor cells (OPC) were cultured in the presence of LPC 18:1-Cy5. Proteins interacting with LPC 18:1-Cy5 were UV crossed linked and cell lysates were separated via isoelectric focusing gel electrophoresis. Band was cut out from gel and processed for mass spectrometry. OPC lysates...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025175 | Pride
Liposome floatation assay Protein-lipid complex Lpc 18:1-cy5 Lpc 18:1 
TranscriptomicsGenetic mosaic analysis of the tumorigenic process distinguishes cell of origin from cell of mutation
Cancer results from molecular mutations occurring in specific cell types, thus determining the cell-of-origin is critical for effective cancer treatment. Inferring such information from terminal tumors can be misleading because malignant tumor cells tend to acquire aberrant properties. Animal models...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-26676 | biostudies-arrayexpress
ProteomicsOPC Cell Culture with LPC 18:1 or LPC 18:1 (both + C13-His)
Rat OPCs were incubated in the presence of LPC 18:1 or LPC 18:0 and C13-His. Cultures controls included no treatment and a positive control for the differentiation of OPCs. LPC 18:1 was administered at 10 uM while C13-His was administered at 10 uM. Samples were process for mass spectrometry to ident...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD025177 | Pride
C13-his Lpc 18:1 Opc 
TranscriptomicsDirect Conversion of Fibroblasts into Oligodendrocyte Progenitor Cells
Many studies have already shown the reprogramming of somatic cells into other cell types such as neural stem cells, blood progenitor cells, and hepatocytes by inducing combinations of transcription factors. One of the recent development in cellular reprogramming is the direct reprogramming, that can...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-52035 | biostudies-arrayexpress
ProteomicsSex-specific extracellular protein composition derived from oligodendrocyte progenitor cells (OPC) under normoxic and hyperoxic conditions
Secretory proteins and extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication and stress response in the brain. Our analysis of the secretome from cell culture supernatants obtained after treating male and female derived primary mouse OPCs with...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD060307 | Pride
Normoxia Mouse Hyperoxia Opc Secretome lc-ms/ms 
GenomicsComprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74648 | biostudies-arrayexpress
TranscriptomicsFibroblast growth factor 9 inhibits remyelination via an off target effect on astrocytes in multiple sclerosis
Failure of remyelination in multiple sclerosis (MS) is associated with inhibition of oligodendrocyte precursor (OPC) differentiation, but the cellular and molecular mechanisms involved remain poorly understood. We now report inflammatory demyelination in MS is associated with localized expression of...
ORGANISM(S): Rattus norvegicus 
2016-02-17 | E-GEOD-44562 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse cumulus cells
Follicle stimulating hormone (FSH) and epidermal growth factor (EGF) are currently used on cumulus-oocyte complexes to mimic the luteinizing hormone surge in vitro and induce oocyte maturation and cumulus expansion. We have previously shown that addition of exogenous recombinant growth differentiati...
ORGANISM(S): Mus musculus 
2011-12-10 | E-GEOD-19327 | biostudies-arrayexpress
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