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ProteomicsProteomic analysis of NFIX over-expression in C2C12 myotubes
Overexpressed either GFP, wild-type (WT) NFIX or a phospho-dead mutant of NFIX in which eight serine residues surrounding S286 were mutated to alanine (S265/267/268/271/272/273/274/275A) was performed C2C12 cells prior to the induction of myogenesis. Cells were harvest 2 days post induction of myoge...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-18 | PXD028718 | Pride
Nfix C2c12 Myoblasts Myotubes 
TranscriptomicsGene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Identification of the molecular changes that promote viability and metastatic behaviour of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate canc...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17482 | biostudies-arrayexpress
ProteomicsZebrafish caudal fin phosphoproteomic of Rps6kb1a/b knockdown
Knocked-down of P70S6K in zebrafish (double knockdown of rps6kb1/2) using embryo Cas9/gRNA RNP injections followed by phosphoproteomics of caudal fin.
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-12-16 | PXD054212 | Pride
Phosphoproteomics P70s6k Rps6kb1 Zebrafish 
ProteomicsProteomic and secretomic analysis of Kusa 4B10 osteoblasts
Kusa 4B10 mesenchymal stem cells (MSCs) were differentiated into osteoblasts over 21 days and either left untreated as controls or made insulin resistant via hyperinsulinemia treatment over 2 days prior to a proteomic and secretomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-16 | PXD054479 | Pride
Insulin resistance Bone Osteoblasts Secretome 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsDual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B cell Leukemias
The oncomir microRNA-125b (miR-125b) is up-regulated in a variety of human neoplastic blood disorders and constitutive up-regulation of miR-125b in mice can promote myeloid and B cell leukemia. We found that miR-125b promotes myeloid and B cell neoplasm by inducing tumorigenesis in hematopoietic pro...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-58900 | biostudies-arrayexpress
ProteomicsASB2beta-induced changes to the skeletal muscle proteome and ubiquitinome
Ubiquitination is a post-translational modification that has been shown to have a range of effects, such as regulating protein function, protein:protein interactions, protein localization, and protein abundance by targeting proteins for degradation by the 26S proteasome. We have previously shown th...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD020040 | Pride
Adeno-associated virus Skeletal muscle Ubiquitin 
ProteomicsCysteine Redox proteomics of PDIA6 over-expressing skeletal muscle
To investigate the role of PDIA6 on changes to specific cysteine residues with altered redox status and insulin senstivity, we overexpressed either GFP control or FLAG-PDIA6 throughout the musculature of 4-day old male C57BL/6J mice via intraperitoneal injection with MyoAAV (Fig. 5F). At 8 weeks of ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD075204 | Pride
Pdia6 Iodo-tmt 
MetabolomicsImprovement of prediction ability by integrating multi-omic datasets in barley

BACKGROUND: Genomic prediction (GP) based on single nucleotide polymorphisms (SNP) has become a broadly used tool to increase the gain of selection in plant breeding. However, using predictors that are biologically closer to the phenotypes such as transcriptome and metabolome may...

2022-03-18 | MTBLS1561 | MetaboLights
TranscriptomicsRate of elongation by RNA polymerase II is influenced by specific gene features and histone modifications
The rate of transcription elongation plays important roles in the timing of expression of full-length transcripts as well as for the regulation of alternative splicing. In this study we coupled Bru-Seq technology with 5,6-dichlorobenzimidazole 1-M-NM-2-D-ribofuranoside (DRB) to estimate the elongati...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-55534 | biostudies-arrayexpress
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