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ProteomicsHIV-1 Nef changes the proteome of T cells extracellular vesicles
Extracellular vesicles (EVs) are biomolecule carriers for intercellular communication in health and disease. Nef is a human immunodeficiency virus (HIV) virulence factor that is released from cells within EVs and is present in plasma EVs of HIV-1 infected individuals. We performed a quantitative pro...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-01-26 | PXD041028 | Pride
Hiv-1 Nef Exosomes Extracelular vesicles 
ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsContribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
Peptides generated by proteasome-catalyzed splicing of non-contiguous amino acid sequences have been shown to constitute a source of non-templated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8+ T cells are key mediators of human i...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2019-11-25 | PXD015489 | Pride
Spliced epitope Peptide splicing Viral escape Mass spectrometry Cd8+ t cell Epitope discovery Proteasome Human leukocyte antigen Immunopeptidome Human immunodeficiency virus 
ProteomicsHLA binding of self-peptides is biased towards proteins with specific molecular functions
Human leukocyte antigen (HLA) is highly polymorphic and plays a key role in guiding adaptive immune responses by presenting foreign and self peptides to T cells. Each HLA variant selects a minor fraction of peptides that match a certain motif required for optimal interaction with the peptide-binding...
ORGANISM(S): Homo sapiens (Human) 
2026-05-28 | PXD023284 | Pride
Antigen presetation Peptides Hla Lc-ms/ms 
UnknownLong-term exposure to exogenous phthalate, masculinity and femininity trait, and gender identity in children: a Chinese 3-year longitudinal cohort study.
Not available
S-EPMC10683128 | biostudies-literature
UnknownComparison of immune checkpoint inhibitors related to pulmonary adverse events: a retrospective analysis of clinical studies and network meta-analysis.
Not available
S-EPMC10875746 | biostudies-literature
ProteomicsMolecular mechanism for selection and control of HIV-1 escape virus by T cells and KIR2DL2+ NK cells
NK cells and CD8+ T cells both contribute to HIV-1 control. These cells not only suppress HIV-1 replication, but also select HIV-1 escape mutant viruses. Most viruses bearing T cell escape mutations are expected to remain susceptible to NK cell suppression, but their control by NK cells is unclear. ...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 1 
2025-08-29 | PXD058766 | Pride
Hiv Nk cells Hla-c Kir 
ProteomicsSaliva peptidome and proteome correlates with oral cancer prognosis
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. Here, we pr...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020111 | Pride
Protease inhibitors Oral squamous cell carcinoma Proteolysis Peptidome Oral cancer 
ProteomicsElucidation of the signatures of proteasome-catalysed peptide splicing
Proteasomes catalyse the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalysed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD021339 | Pride
Protein splicing Proteasome Splicing mechanism 
UnknownCase Study of Diesters of o-Phthalic Acid in Surface Waters with Background Levels of Pollution.
Not available
S-EPMC10611372 | biostudies-literature
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