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ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsComprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. Employing an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics on re...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD037134 | Pride
Glycomics Lymph node metastasis Glycoproteomics Glycosylation Glycoproteome Oral cancer 
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
TranscriptomicsA Novel Human Leiomyoma Tissue Derived Matrix for Cell Culture Studies
The composition of the matrix molecules is important in in vitro cell culture experiments of e.g. human cancer invasion and vessel formation. Currently, the mouse Engelbreth-Holm-Swarm (EHS) sarcoma -derived products, such as Matrigel®, are the most commonly used tumor microenvironment mimicking (T...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-68722 | biostudies-arrayexpress
UnknownMapping N-linked glycosylation of carbohydrate-active enzymes in the secretome of Aspergillus nidulans grown on lignocellulose.
Not available
S-EPMC4977673 | biostudies-literature
UnknownPleomorphic adenoma and carcinoma ex-pleomorphic adenoma tumorigenesis: A proteomic analysis.
Not available
S-EPMC12021308 | biostudies-literature
ProteomicsThermus filiformis proteome analysis
Proteome analysis of thermophilic bacteria Thermus filiformis cultivated in different temperatures (63, 70 and 77 Celsius degree)
ORGANISM(S): Thermus Filiformis (ncbitaxon:276) 
2016-04-16 | MSV000079653 | MassIVE
UnknownCD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin.
Not available
S-EPMC8362802 | biostudies-literature
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1
We have previously shown that Thioredoxin-1 (Trx-1) binds to the cytoplasmic domain of ADAM17 (ADAM17cyto), A Disintegrin And Metalloprotease 17, and that the destabilization in their interface of interaction favors the Trx-1 dimeric and inactive state. These studies opened the question of whether A...
ORGANISM(S): Homo Sapiens 
2021-03-12 | PXD020016 | panorama
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