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ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsComprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. Employing an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics on re...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD037134 | Pride
Glycomics Lymph node metastasis Glycoproteomics Glycosylation Glycoproteome Oral cancer 
ProteomicsTargeting of CD30-negative tumor cells in DLBCL with Brentuximab-vedotin through CD30-positive extracellular vesicles, in vitro
Evaluate the composition of extracellular vesicles by mass spectrometry coupled with liquid chromatography.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025442 | Pride
Tumor cells Extracellular vesicles Cd30 
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD027984 | panorama
ProteomicsMultisite proteome provides insights into the biology and prognostic markers for head and neck cancer
The poor prognosis of head and neck cancer (HNC) is largely associated with the presence of metastasis in the lymph nodes (LN). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN tissues, saliva, and blood cells, reveals insights into the bio...
ORGANISM(S): Homo Sapiens 
2022-11-22 | PXD036311 | panorama
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