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ProteomicsBenchmarking Sample Preservation Strategies for Clinical Single-Cell Proteomics
Single-cell proteomics (SCP) enables direct characterization of cellular states at proteome resolution but remains limited in clinical studies due to challenges in sample collection, storage, and transportation. Here, we systematically evaluated preservation strategies for SCP by comparing fresh, cr...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD071894 | Pride
ProteomicsMapping the interactome of OSCC prognostic-associated proteins NDRG1 and PGK1 through proximity labeling using TurboID
Oral squamous cell carcinoma (OSCC) is a prevalent type of head and neck cancer, accounting for more than 90% of all oral malignancies worldwide. The identification of diagnostic and prognostic markers for OSCC is crucial for improving patient outcomes, as early detection and treatment are critical ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048046 | Pride
Ndrg1 Oral cancer Pgk1 Turboid Interactome Proximity labeling Prognostic 
ProteomicsCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals new features of arthritogenic alphaviruses
Characterize the glycosylation sites in E1 and E2, which are transmembrane proteins that are organized in heterodimers.
ORGANISM(S): Homo sapiens (Human) Mayaro virus (strain Brazil) 
2021-05-28 | PXD024432 | Pride
Cryo-em structure  alphaviruses  mass spectrometry  glycosylation 
ProteomicsSaliva peptidome and proteome correlates with oral cancer prognosis
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. Here, we pr...
ORGANISM(S): Homo sapiens (Human) 
2020-11-13 | PXD020111 | Pride
Protease inhibitors Oral squamous cell carcinoma Proteolysis Peptidome Oral cancer 
ProteomicsGlutaminase C N-terminus phosphorylation decreases its enzymatic activity
The gene GLS generates the phosphate activated glutaminase C (GAC) isoform by alternative splicing. GAC, compared to the other isoform, kidney-type glutaminase (KGA), has been characterized as more active and particularly important for cancer cell growth. Very little is known about post-translationa...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD008338 | Pride
Metabolism Mapk1 Breast cancer Glutaminase Phosphorylation 
ProteomicsLimited proteolysis-mass spectrometry of saliva maps proteome-wide structural changes associated with oral cancer aggressiveness.
Considering that these potential diagnostic and prognostic targets may be regulated by events that do not imply variation in protein abundance levels, we investigated the hypothesis that changes in protein conformation can be associated with diagnosis and prognosis, revealing biological processes an...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD042574 | Pride
Oral cance Limited proteolysis Saliva Functional proteomics Mass spectrometry Structural proteomic Protein post-translational modification Prognosis 
ProteomicsReductionist approach using primary and metastatic cell-derived extracellular vesicles prospect proteins associated with oral cancer prognosis
Oral squamous cell carcinoma (OSCC) shows high mortality rates that are largely associated with the presence of lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Here, we used a reductionist approach mapping the proteomic, miRNA, metabolomic and lipidom...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD019216 | Pride
Metabolomics Mirna Multi-omics approach Lipidomics Lymph node metastasis Extracellular vesicles Oral cancer squamous cell carcinoma Proteomics Prognosis 
ProteomicsComprehensive glycoprofiling of oral tumours associates N-glycosylation with lymph node metastasis and patient survival
While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. Employing an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics on re...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD037134 | Pride
Glycomics Lymph node metastasis Glycoproteomics Glycosylation Glycoproteome Oral cancer 
ProteomicsMetformin impairs cisplatin effects in cell size and proliferation of A549 lung cancer cells, modulating the mTOR and other metabolic pathways.
Lung cancer is the leading cause of cancer death worldwide and reports innate and acquired therapeutic resistance to cisplatin. Metformin (MET), an antidiabetic agent with potential antitumor activity, overcomes cisplatin resistance in some cancers through AMPK-dependent and independent mechanisms. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017645 | Pride
Silac Proteomic Nsclc  cisplatin resistance  metformin  mtor pathway 
ProteomicsTargeting of CD30-negative tumor cells in DLBCL with Brentuximab-vedotin through CD30-positive extracellular vesicles, in vitro
Evaluate the composition of extracellular vesicles by mass spectrometry coupled with liquid chromatography.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025442 | Pride
Tumor cells Extracellular vesicles Cd30 
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