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UnknownOhio Modified Arm-Motor Ability Test (OMAAT): An Optimized Measure of Upper Extremity Functional Limitation in Hemiparetic Stroke.
Not available
S-EPMC8722480 | biostudies-literature
ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
ProteomicsThe Quantitative Changes in the Yeast Hsp70 and Hsp90 Interactomes upon DNA Damage
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. In this study, we applied quantitative affinity-purification mass spectrometry (AP-MS) proteomics to understand the protein network through which Hsp70 and Hsp90 exe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-12-08 | PXD001284 | Pride
Saccharomyces cerevisiae 18o quantitation Ltq orbitrap xl Lc-ms/ms 
ProteomicsNon-intein splicing of RB47 - Activation of an Endoribonuclease by Non-intein Protein Splicing
The poly A binding protein RB47 was purified from C. reinhardtii chloroplasts and was found to have endoribonuclease activity. MS analysis suggested that an internal non-conserved linker (NCL)sequence was absent from the native protein. Recombinant, full length RB47 protein, including the NCL did no...
ORGANISM(S): Chlamydomonas reinhardtii 
2018-10-27 | PXD004285 | Pride
Rb47 C. reinhardti Chloroplast Intein 
ProteomicsSpectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from 1-3, and subunits. Here, we isolate distinct GABAARs from the brain and interrogate their composition using quantitative pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD038703 | Pride
Ais Gaba a receptors Spectrins 
ProteomicsChemotherapy-induced cellular senescence is characterized by aberrant lipid regulation and lipid peroxidation
As normal cells approach their proliferative limit, they arrest to undergo replicative senescence, displaying large cell size, flat morphology and activation of senescence-associated beta-galactosidase (SA-b-Gal). A subset of normal or tumor cells exposed in vitro or in vivo to chemotherapy agents s...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-06 | PXD006216 | Pride
Maxquant lfq Lipid peroxidation Mus Q-exactive Chemotherapy-induced senescence Quant proteomics 
ProteomicsMevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here we report a novel role for statin-based treatment of HNSCCs as an actionable and safe adjuvant to radiotherapy. Proteomic profiling and comparison of radiosensitive and radioresistant HNSCCs rev...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD007188 | Pride
Q-exactive Hnscc Pitavastatin Ddr Senescence Mevalonate pathway Lfq quantification. 
ProteomicsSynthetic circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation
MicroRNA (miRNA) sponges containing miRNA complementary binding sites constitute a potentially useful strategy for miRNA-inhibition therapeutics in cancer patients. Recently, naturally occurring circular RNAs (circRNAs) have been revealed to function as efficient microRNA sponges. We hypothesized th...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008584 | Pride
Synthetic circular rna  microrna sponge  microrna loss of function  gastric carcinoma  gene therapy 
ProteomicsO-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD010820 | Pride
Hbp pathway Mass spectrometry Dna repair Shoga Lfq quantification Shogt O-glcnacylation Chromatin modification Q-exactive 
ProteomicsPhosphorylation of GABAAR α2 subunit
γ-aminobutyric acid type A receptors (GABAARs) mediate fast synaptic inhibition. Phosphorylation governs GABAARs function and trafficking in α4, β and γ subunits. However, phosphorylation of other subunits has not been demonstrated. Here we show that the α2 subunit is phosphorylated on S359.
ORGANISM(S): Mus musculus (Mouse) 
2020-07-03 | PXD019597 | Pride
Α2 Phosphorylation Gabaar 
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