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ProteomicsTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions
Estrogen receptor-alpha (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER-transcriptional activity is not clear. We sought to identify the contribution of GATA3 to...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD019438 | Pride
Breast cancer Estrogen receptor alpha Tet2 Qplex-rime 
ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
ProteomicsMulti-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptionalrepression during oogenesis
EHMT1 (also known as GLP) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory dimerization with EHMT2 (also known as G9A). Here, we investigated the role of EHMT1 in the oocyte in comparison to EHMT2 using oocyte-specifi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD030265 | Pride
Epigenetics Histone modification Histone methyltransferase Glp/ehmt1 H3k9 methylation Dna methylation Oocyte 
ProteomicsA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering the mechanisms underlying diseases such as cancer. To enable the in-depth analysis of protein interactions in chromatin-associated protein complexes, we have previously developed a met...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD007968 | Pride
Breast cancer Proteomics Qplex-rime Tmt 4-hydrotamoxifen Rime Clinical samples Isobaric labelling Patient derived xenografts (pdx) Estrogen receptor alpha Interactome 
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