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ProteomicsFIKK4.1-FIKK4.2 protein environment in Plasmodium falciparum infected red blood cells
In this project we used proximity labelling to investigate the environment of 2 P.falciparum kinases, FIKK4.1 and FIKK4.2, exported in the infected red blood cell (iRBCs), by fusing them to a biotin ligase. Peptide-level analysis was used to obtain more information about the topography of these 2 ki...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum NF54 
2025-05-20 | PXD048966 | Pride
Plasmodium falciparum Exported fikk kinases Peptide-level proximity labelling Lc-ms/ms 
ProteomicsDynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics
Epithelial colonisation is often a critical first step in bacterial pathogenesis, however, different bacterial species utilise several different receptors at the cell membrane interface to adhere to cells. We have previously demonstrated that interference of the human tetraspanin, CD9, can reduce ad...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus subsp. aureus NCTC 8325 Neisseria meningitidis serogroup B (strain MC58) 
2025-10-28 | PXD058283 | Pride
Epithelial Cd9 Neisseria meningitidis Staphylococcus aureus Bacteria Proximity labelling Tetraspanin 
ProteomicsYeast Sis1 proximity labelling during heat shock
Proximity interactome labelling of Sis1 APEX2 during heat shock revealed its comprehensive interactome.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-18 | PXD039068 | Pride
Sis1 Heat shock Apex2 Proximity labeling 
ProteomicsLAMP1 and LAMP2 proximity labelling
The aim of the study is to capture the endogenous protein interactomes of LAMP1 and LAMP2A in human neurons using proximity labelling. This was carried out using full-length LAMP1 or LAMP2A fused to the light-activated biotin ligase LOV-Turbo, in cortical neurons differentiated from human iPSCs (I3...
ORGANISM(S): Homo sapiens (Human) 
2026-01-21 | PXD067562 | Pride
Lov-turbo Lamp1 Turboid Lamp2a 
ProteomicsDynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics
Epithelial colonisation is often a critical first step in bacterial pathogenesis, however, different bacterial species utilise several different receptors at the cell membrane interface to adhere to cells. We have previously demonstrated that interference of the human tetraspanin, CD9, can reduce ad...
ORGANISM(S): Neisseria meningitidis serogroup B Homo sapiens (Human) Staphylococcus aureus 
2025-10-28 | PXD067302 | Pride
Neisseria meningitidis Staphylococcus aureus Cde9 
ProteomicsMapping AT1R biased signaling using proximity-labeling and proteomics identifies diverse actions of biased agonists
Angiotensin II type 1 receptors (AT1Rs) are one of the most widely studied G protein-coupled receptors. To fully appreciate the diversity in cellular signaling profiles activated by AT1R transducer-biased ligands, we utilized peroxidase-catalyzed proximity labeling to capture proteins in close prox...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD023814 | Pride
Apex Proximity labeling At1r Biased agonism 
ProteomicsProbing kinase proximity interactome modulation upon drug treatment by miniTurboID proximity labelling
In a systematic effort to profile kinase inhibitors, which also act as degraders, we identified multiple hit compounds. These were subjected to detailed mechanism of action elucidation including analysis of the perturbed interactome and its effect on degradation. For our first example, LYN, Src inhi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD062184 | Pride
Kinase inhibitors Tmt 
ProteomicsDRM6 and DLO1 TurboID-based proximity labelling proteomics
TurboID-based proximity labeling of DMR6 and DLO1 identified several candidate interactors, including a putative F-box protein that may contribute to their SCF-dependent turnover.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Nicotiana benthamiana 
2026-03-06 | PXD063821 | Pride
Skp1 Drm6 Salicylic acid Dlo1 Ask1 Proteasome Arabidopsis 
ProteomicsArabidopsis thaliana ASK1 proximity labeling upon Pst DC3000 infection
we used proximity labeling of ASK1, a core SCF adaptor, to profile dynamic changes in SCF-associated networks during Pseudomonas syringae infection. This analysis revealed widespread remodeling of F-box proteins and immune-related regulators, including several previously uncharacterized components.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-05 | PXD063820 | Pride
Skp1 Turboid Ask1 Proteasome Proximity labelling Arabidopsis 
ProteomicsBioID2 interactome of wild-type SYCP1 versus the D918–942 mutant
This dataset comprises a tandem mass tag (TMT)–based quantitative proteomic analysis of proteins proximal to SYCP1 identified using BioID proximity labelling. Two independent BioID experiments were performed using distinct SYCP1 constructs: an N-terminal Myc-tagged SYCP1 and a C-terminal HA-tagged S...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD072359 | Pride
Sycp1  bioid  proximity labeling 
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