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TranscriptomicsRibosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 M-BM-5M
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eIF2. However, the persistent translation of certain mRNAs is required for deployment of an adequate s...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-55195 | biostudies-arrayexpress
UnknownConsistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype.
Not available
S-EPMC4334507 | biostudies-literature
ProteomicsPhosphoproteome of Monascus purpureus
MpSTE1 mediates the phosphoylation of downstream proteins which control hyphal branching in M. purpureus. The phosphoproteomes of the wild-type (WT) and ΔmpSTE1 strains were compared to pinpoint proteins specifically phosphorylated in an MpSTE1-dependent manner. Since the gene mpSTE1 was disrupted i...
ORGANISM(S): Monascus Purpureus 
2023-12-29 | PXD048208 |
ProteomicsAnalysis of CNK1-SAM domain phosphorylation sites
Scaffold proteins such as CNK1 are hubs for coordinating signalling pathways. Here, we demonstrate that CNK1 is a crucial transducer of growth factor-stimulated and oncogenic signalling. Activation of CNK1 depends on its dimerization executed by the N-terminal sterile motif alpha (SAM) domain. Accor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD003797 | Pride
Cnk1 akt in vitro kinase egf stimulation 
ProteomicsAnalysis of CNK1-SAM domain phosphorylation sites
Scaffold proteins such as CNK1 are hubs for coordinating signalling pathways. Here, we demonstrate that CNK1 is a crucial transducer of growth factor-stimulated and oncogenic signalling. Activation of CNK1 depends on its dimerization executed by the N-terminal sterile motif alpha (SAM) domain. Accor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD003831 | Pride
Cnk1 akt in vitro kinase egf stimulation 
UnknownEffects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE-/- mice.
Not available
S-EPMC7206822 | biostudies-literature
ProteomicsMercury Uniquely Alters B-Cell Protein Phosphorylation Profiles
To test the hypothesis that HgCl2 acts as a phospho-tyrosine phosphatase inhibitor in B-cells, we treated the WEHI-231 cell line for 10 min with HgCl2 at 100 uM or 250 uM, okadaic acid at 100 nM or pervanadate at 25 uM and analyzed the phosphoproteome by TiO2 affinity chromatography and LC-MS/MS. ...
ORGANISM(S): Mus musculus (Mouse) 
2013-12-10 | PXD000312 | Pride
Phosphoprotein B-cell Mercury Phosphoylation Pervanadate Hg 
ProteomicsThe phosphorylation of the Smad2/3 linker region by Nemo-like kinase regulates TGF-β signaling
Smad2 and Smad3 (Smad2/3) primarily mediates the transforming growth factor-β (TGF-β) signaling that drives cell proliferation, differentiation, and migration. The dynamics of the Smad2/3 phosphorylation provides the key mechanism for regulating the TGF-β signaling pathway. Here we identified NLK as...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023957 | Pride
Smad3 Phosphorylation Smad2 Nlk 
GenomicsHomo sapiens
Ribosome profiling data obtained from HEK293T cells 30 minutes after treatment with arsenite to a final concentration of 40 µM
PRJNA238879 | ENA
ProteomicsPhosphoproteomics of Jatropha curcas seedling under chilling stress
As a promising energy plant for biodiesel, Jatropha curcas is a tropical and subtropical shrub. Chilling is a major abiotic stress affecting the growth and development of J. curcas. In this study, we adopt the phosphoproteomic analysis, physiological measurement, ultrastructure observation to illust...
ORGANISM(S): Jatropha curcas 
2019-01-09 | PXD011438 | Pride
Jatropha curcas  phosphoproteomics  seedling  chilling stress  regulated mechanism 
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