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GenomicsCondensin association with chromosomes depends on a DNA binding domain formed by its HEAT-repeat subunits
Condensin protein complexes play central roles in the three-dimensional organization of chromosomes during mitotic and meiotic cell divisions. How condensin interacts with its chromatin substrates to promote sister chromatid decatenation and segregation is largely unknown. Previous work suggested th...
ORGANISM(S): Saccharomyces cerevisiae 
2014-05-16 | E-GEOD-55948 | biostudies-arrayexpress
ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes, p2
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in developing optimized leads. We have developed a drug target deconvolution approach with an automated data analysis pipeline, based on limi...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD018204 | Pride
Limited proteolysis Dia-ms Lip-ms Drug identification 
ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes
Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in developing optimized leads. We have developed a drug target deconvolution approach with an automated data analysis pipeline, based on limi...
ORGANISM(S): Homo sapiens (Human) Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) Saccharomyces cerevisiae (Baker's yeast) 
2020-09-09 | PXD015446 | Pride
Limited proteolysis Dia-ms Lip-ms Drug identification 
ProteomicsA map of protein-metabolite interactions reveals principles of chemical communication
Application of a novel mass spectrometry-based high-throughput workflow (LiP-SMap) and data resource based on limited proteolysis (LiP) of complex samples. Proteome-wide limited proteolysis sites were obtained in different conditions to infer ligand-induced and protein-protein interaction induced co...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2018-01-04 | PXD006543 | Pride
Small molecules Limited proteolysis Lip-smap Dia-ms E.coli 
ProteomicsPooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
Microproteins encoded by short open reading frames (sORFs) of less than 100 codons have been predicted to constitute a substantial fraction of the eukaryotic proteome. However, relevance and roles of the majority of microproteins remain undefined because only a small fraction of these intriguing cel...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD057806 | Pride
Microprotein 
ProteomicsNetwork rewiring of homologous recombination during mitotic proliferation and meiosis
Homologous recombination is essential for high-fidelity DNA repair during mitotic proliferation and meiosis. Yet, context-specific modifications must tailor the recombination machinery to avoid, or enforce, formation of reciprocal exchanges – crossovers – between recombining chromosomes. To obtain m...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-07-31 | PXD012486 | Pride
Crossing-over Yen1/gen1 Mlh1-mlh3-exo1 Sgs1/blm-top3-rmi1 Slx1-slx4(btdb12) Mus81-mms4/eme1 Srs2/rtel1 Cell cycle Mph1/fancm Holliday junction Dna repair 
UnknownTocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial.
Not available
S-EPMC7576974 | biostudies-literature
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