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ProteomicsMultilevel proteomics reveals common and specific host perturbations by Monkeypox and Vaccinia viruses
The global spread of Monkeypox virus (MPXV) has resulted in the urgent need for an in-depth molecular characterization of the virus infection. Multiple omics studies on Vaccinia virus have extended our knowledge of poxvirus pathophysiology (REFs). Nevertheless, there are no comparative studies that ...
ORGANISM(S): Homo sapiens (Human) Monkeypox virus Orthopoxvirus 
2024-07-25 | PXD040889 | Pride
Human Poxvirus Lc-ms Monkeypoxvirus 
ProteomicsMultilevel proteomics reveals common and specific host perturbations by Monkeypox and Vaccinia viruses (full proteome)
The global spread of Monkeypox virus (MPXV) has resulted in the urgent need for an in-depth molecular characterization of the virus infection. Multiple omics studies on Vaccinia virus have extended our knowledge of poxvirus pathophysiology (REFs). Nevertheless, there are no comparative studies that ...
ORGANISM(S): Homo sapiens (Human) Monkeypox virus Orthopoxvirus 
2024-07-25 | PXD040811 | Pride
Human Poxvirus Shotgun-proteomics Vaccinia virus Monkeypox virus 
ProteomicsmRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus
Alternative polyadenylation (APA) leading to changes of mRNA 3’UTRs has been associated to numerous pathologies but its molecular origin and functional consequences often remain enigmatic. We show that all Influenza A virus (IAV) strains cause APA of host transcripts and mapped the effect to a dru...
ORGANISM(S): Homo sapiens (Human) 
2023-07-12 | PXD040456 | Pride
Iav Ns1 Semliki forest virus Pr8 Sfv Influenza a 
ProteomicsFluAV vRNP interactome - A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012275 | Pride
Influenza Rnps Fluav Ap-lc-ms/ms 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-04-30 | PXD045916 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD045783 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD045812 | Pride
Viral replication Live-cell imaging Sars-cov-2 Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsThe ISG Atlas: A Loss-Of-Function Analysis Characterizes Antiviral Properties of Interferon Stimulated Genes
The innate immune system requires the activity of interferon-stimulated genes (ISGs) to mount its protective response against viruses and other pathogens. However, the sensitivity of ISGs against viruses varies widely, and the spectrum of antiviral activities of ISGs is only partially understood. Ut...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD045929 | Pride
Viral replication Live-cell imaging Sars-cov-2 Rtcb Innate immune system Interferon-stimulated genes (isgs) Arrayed knock-out screen Proteomics 
ProteomicsMolluscum Contagiosum Virus Protein MC089 Inhibits Interferon Regulatory Factor 3 Activation
Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes a highly common but mild infection characterised by distinctive and persistent papular skin lesions. These lesions can persist for long periods without an effective clearance response from the host. MCV, like all poxviruses, ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD054178 | Pride
Molluscum contagiosum virus  mc089  innate immunity  ikkε  tbkbp1  nap1  mavs. 
ProteomicsMDM2 influences ACE2 stability and SARS-Cov2 uptake
The Angiotensin-converting enzyme 2 (ACE2) receptor is the central entry point for SARS-Cov2. Several SAR-Cov2 substrains have developed mutations in their spike protein to maximize their use of ACE2, e.g. to strengthen ACE2 binding for increased uptake or adapt to specific amino acid properties of ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-09-08 | PXD040891 | Pride
Human Ubiquitination Sars-cov2 Ace2 
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