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ProteomicsRat Cortical Primary Neuronal Culture with NRN1 Protein Treatment
Cortical rat neuronal culture, lysis and proteolytic digestion Primary rat cortical neurons were generated from E18 Sprague-Dawley rat embryos with minor modifications (Swanger, Mattheyses et al. 2015, Henderson, Greathouse et al. 2019). Neurons were cultured at a density of 4x105 cells per well in...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040867 | Pride
Rat primary cortical neurons Nrn1 Neuroproteomics 
ProteomicsScilifelab-AffinityProteomics-BIONMD-384plex.Antibody.Bead.Array_BurcuAyoglu
Antibody suspension bead array based profiling of plasma samples collected from Duchenne and Becker muscular dystrophy patients and non-diseased controls and carriers at 4 different clinical sites
ORGANISM(S): Homo sapiens 
2014-05-10 | E-MTAB-2564 | biostudies-arrayexpress
ProteomicsIdentification of novel Kv1.3 channel dependent mechanisms in microglial activation
Pro-inflammatory microglia contribute to disease progression in neuroinflammatory and neurodegenerative diseases. We identify novel Kv1.3 channel-dependent molecular and cellular mechanisms during microglial activation and unravel a Kv1.3-dependent pathway for MHCI-restricted antigen presentation by...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006753 | Pride
Inflammation Potassium channel Systems pharmacology Microglia Bv2 
MetabolomicsAn Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid phenotyping for large epidemiological studies to reveal the detailed associati...
2024-02-02 | MTBLS4461 | MetaboLights
ProteomicsTargeted Degradation of Aberrant Tau in Frontotemporal Dementia Patient-Derived Neuronal Cell Models
Tauopathies are a family of neurodegenerative diseases characterized by a shared pathology of aberrant forms of tau protein accumulation leading to neuronal death in focal areas of the brain. Positron emission tomography (PET) tracers that bind to tau aggregates are used to aid diagnosis, but there ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD012515 | Pride
Crl4 Tau Crbn Frontotemporal dementia Protac Ubiquitin 
ProteomicsCharacterization of detergent insoluble proteome in chronic traumatic encephalopathy
Proteomic sequencing of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer’s disease and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy are limited, but may provide important new insights into this di...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD007694 | Pride
Proteostasis Ad Detergent insoluble proteome Human brain cte Alzheimer's disease Dementia pugilistica 
ProteomicsMiddle-down proteomics reveals RNA binding proteins harbor dense sites of methylation and phosphorylation
Arginine (Arg)-rich RNA-binding proteins play an integral role in RNA metabolism. Post-translational modifications (PTMs) within Arg-rich domains, such as phosphorylation and methylation, regulate multiple steps in RNA metabolism. However, the identification of PTMs within Arg-rich domains with comp...
ORGANISM(S): Homo sapiens (Human) 
2020-01-31 | PXD015208 | Pride
Middle-down Rs protein Etd Decision tree Basic-acidic domains 
ProteomicsReflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
In the past decades many studies reported the presence of Endoplasmic Reticulum (ER) resident proteins in the cytosol. However the mechanisms by which these proteins relocate and whether they exert cytosolic functions remain unknown. We found that select ER luminal proteins accumulate in the cytosol...
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD023567 | Pride
Tumor cells Upr Endoplasmic reticulum 
ProteomicsMouse kidney and cell lines LC-MS/MS
Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living organisms. During Zn limitation, specialized enzymes called metallochaperones are predicted to allocate Zn to specific metalloproteins. This function has been putatively assigned to G3E GTPase COG0523 proteins,...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD031516 | Pride
Mouse Targeteed Shotgun Zinc 
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