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ProteomicsProteomic profiles in cardiomyocytes exposed to ionizing radiation and resveratrol: potential radioprotective mechanisms of the different resveratrol pretreatment regimens
Resveratrol, a plant-derived antioxidant, may protect against radiation by modulating cellular metabolism and response to stress. Here, we explored its effects on human cardiomyocytes exposed to ionizing radiation. Resveratrol (5 µM) was administered for 1, 7, and 30 days before a single 2 Gy dose i...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD069084 | Pride
Radiation  resveratrol  radioprotection  proteomics 
ProteomicsBlood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-ß1 signaling mechanism
Background: Prostate cancer (PCa) is the second most common type of tumor diagnosed in men and the fifth leading cause of cancer-related death in male patients. The response of metastatic disease to standard treatment is heterogeneous. As for now, there is no curative treatment option available for ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052973 | Pride
Liquid biopsy Aldh1a1 Tgf-ß1 Mmp11 Prostate cancer Metastasis 
ProteomicsPrognostic value of molecular intratumor heterogeneity in primary oral cancer and its lymph node metastases assessed by mass spectrometry imaging
Different aspects of intra-tumor heterogeneity (ITH), which are associated with development of cancer and its response to treatment, have postulated prognostic value. Here we searched for the potential association between phenotypic ITH analyzed by mass spectrometry imaging (MSI) and the prognosis o...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034958 | Pride
Cancer prognosis  head and neck squamous cell carcinoma  intratumor heterogeneity  long-term outcome  mass spectrometry imaging  tumor microenvironment 
ProteomicsTranscriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes
Transcriptomic analyses revealed hundreds of p53-regulated genes, however these studies used a limited number of cell lines and p53-activating agents. Therefore, we searched for candidate p53-target genes by employing stress factors and cell lines never used in high-throughput search for p53-regulat...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD036860 | Pride
Transcriptome Secretome P53  innate immunity  wnt signaling 
ProteomicsMolecular profiling of tumor-derived exosomes in plasma of patients with melanoma
By isolation of exosomes from body fluids such as serum or plasma with the use of a gel filtration method developed for this purpose, we showed that the level of exosomes in patients with melanoma is higher and may be associated with progression of the tumor and treatment response. By applying the t...
ORGANISM(S): Homo sapiens (Human) 
2021-08-12 | PXD021285 | Pride
Melanoma cell-derived exosomes (mtex) Proteomics High-resolution mass spectrometry (hrms) Tumor-derived exosomes (tex) Plasma Small extracellular vesicles (sev) Human 
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells
Exosomes secreted by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for the generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-31 | PXD032080 | Pride
Bystander effect Exosomes Mass spectrometry Q exactive plus Phosphoproteomics 
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells.
Exosomes released by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were stim...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD032143 | Pride
Bystander effect  exosomes  ionizing radiation  non-targeted effects of radiation  replication stress 
ProteomicsIntra-tumor heterogeneity revealed by mass spectrometry im-aging is associated with the prognosis of breast cancer
Intra-tumor heterogeneity (ITH) results from coexistence of genetically distinct cancer cell (sub)populations, their phenotypic plasticity, and the presence of heterotypic components of the tumor microenvironment (TME). Here we addressed potential association between phenotypic ITH revealed by mass ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027878 | Pride
Her2-positive breast cancer  intra-tumor heterogeneity  mass spectrometry imaging  prognosis  long-term outcome  tumor microenvironment 
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