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TranscriptomicsHigh resolution view of bacteriophage lambda gene expression by ribosome profiling
Bacteriophage lambda is one of the most extensively studied organisms, and has been a primary model for understanding basic modes of genetic regulation. Here we examine the progress of lambda gene expression during phage development by ribosome profiling, and thereby provide a very high resolution ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-07-01 | E-GEOD-47509 | biostudies-arrayexpress
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
ProteomicsPAXX and its paralogues synergistically direct DNA polymerase I activity in DNA repair
In this study, we characterised the interactomes of PAXX and its paralogs, XLF and XRCC4, to show that these factors share the ability to interact with DNA polymerase lambda (Poll), stimulate its activityand are required for the recruitment of Poll to laser-induced DNA damage sites.
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD010891 | Pride
Polymerase lambda Xrcc4 Double strand breaks Nhej Paxx Dna repair Xlf Dna-pkcs 
TranscriptomicsNascent strand with BrdU or lambda exonuclease
Nascent strand were purified with either the BrdU or the lambda exonuclease methods from culture human basophilic erythroblasts and sequenced/ Two methods were compared to isolated the Nascent strand, lambda exonuclease digestion or immunoprecipitation after pulse labelling with BrdU The following...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-50976 | biostudies-arrayexpress
GenomicsHaploid genome-wide screens for essential components and negative regulators of interferon lambda signaling in human cells
We undertook a unbiased genome-wide haploid genetic screen to identify new components in interferon lambda signaling. In addition, we performed a genome-wide screen to identify genes that repress spontaneous activation of interferon stimulated genes in the absence of interferon. Both of these screen...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5866 | biostudies-arrayexpress
UnknownDNA polymerase λ inactivation by oxidized abasic sites.
Not available
S-EPMC3566640 | biostudies-literature
UnknownStructure-function studies of DNA polymerase λ.
Not available
S-EPMC4018081 | biostudies-literature
UnknownPromiscuous mismatch extension by human DNA polymerase lambda.
Not available
S-EPMC1904104 | biostudies-literature
UnknownLoop 1 modulates the fidelity of DNA polymerase lambda.
Not available
S-EPMC2938210 | biostudies-literature
UnknownInteraction between DNA Polymerase lambda and anticancer nucleoside analogs.
Not available
S-EPMC2878035 | biostudies-literature
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